Gene description for PSTPIP1
Gene name proline-serine-threonine phosphatase interacting protein 1
Gene symbol PSTPIP1
Other names/aliases CD2BP1
CD2BP1L
CD2BP1S
H-PIP
PAPAS
PSTPIP
Species Homo sapiens
 Database cross references - PSTPIP1
ExoCarta ExoCarta_9051
Entrez Gene 9051
HGNC 9580
MIM 606347
UniProt O43586  
 PSTPIP1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for PSTPIP1
Molecular Function
    actin binding GO:0003779 IEA
    protein phosphatase binding GO:0019903 IEA
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 TAS
    cell migration GO:0016477 IEA
    cell adhesion GO:0007155 IEA
    innate immune response GO:0045087 TAS
    nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway GO:0035872 TAS
    endocytosis GO:0006897 IEA
    inflammatory response GO:0006954 IEA
Subcellular Localization
    stress fiber GO:0001725 IEA
    uropod GO:0001931 IEA
    lamellipodium GO:0030027 IEA
    membrane GO:0016020 IDA
    actomyosin contractile ring GO:0005826 IEA
    cleavage furrow GO:0032154 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified PSTPIP1 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for PSTPIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RPL32 6161
Affinity Capture-MS Homo sapiens
2 WASF2 10163
Invitro Homo sapiens
Invivo Homo sapiens
3 BZW2 28969
Affinity Capture-MS Homo sapiens
4 RPL37A 6168
Affinity Capture-MS Homo sapiens
5 ABL1 25
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
6 DDX21 9188
Affinity Capture-MS Homo sapiens
7 RPL21 6144
Affinity Capture-MS Homo sapiens
8 RPL3 6122
Affinity Capture-MS Homo sapiens
9 WASF1 8936
Invivo Homo sapiens
Invitro Homo sapiens
10 RPL34 6164
Affinity Capture-MS Homo sapiens
11 FDFT1 2222
Affinity Capture-MS Homo sapiens
12 PTPN12  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 WAS 7454
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
14 RPL35 11224
Affinity Capture-MS Homo sapiens
15 RUVBL1 8607
Affinity Capture-MS Homo sapiens
16 RPL18A 6142
Affinity Capture-MS Homo sapiens
17 RPL31 6160
Affinity Capture-MS Homo sapiens
18 RPL35A 6165
Affinity Capture-MS Homo sapiens
19 CD2 914
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
20 RPL36 25873
Affinity Capture-MS Homo sapiens
21 RPL23A 6147
Affinity Capture-MS Homo sapiens
22 BZW1 9689
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PTPN18 26469
Invivo Homo sapiens
Invivo Homo sapiens
Invivo Homo sapiens
24 RPL26 6154
Affinity Capture-MS Homo sapiens
25 RPL36A  
Affinity Capture-MS Homo sapiens
26 ATIC 471
Affinity Capture-MS Homo sapiens
27 RPL29 6159
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PSTPIP1 is involved
PathwayEvidenceSource
The NLRP3 inflammasome TAS Reactome





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