Gene description for MOS
Gene name v-mos Moloney murine sarcoma viral oncogene homolog
Gene symbol MOS
Other names/aliases MSV
Species Homo sapiens
 Database cross references - MOS
ExoCarta ExoCarta_4342
Vesiclepedia VP_4342
Entrez Gene 4342
HGNC 7199
MIM 190060
UniProt P00540  
 MOS identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for MOS
Molecular Function
    protein kinase activity GO:0004672 IBA
    protein serine/threonine kinase activity GO:0004674 ISS
    3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA
    DNA-dependent protein kinase activity GO:0004677 IEA
    AMP-activated protein kinase activity GO:0004679 IEA
    eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA
    MAP kinase kinase kinase activity GO:0004709 ISS
    ribosomal protein S6 kinase activity GO:0004711 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    histone H3S10 kinase activity GO:0035175 IEA
    histone H3T11 kinase activity GO:0035402 IEA
    histone H3T6 kinase activity GO:0035403 IEA
    histone H2AXS139 kinase activity GO:0035979 IEA
    histone H3S28 kinase activity GO:0044022 IEA
    histone H4S1 kinase activity GO:0044023 IEA
    histone H2AS1 kinase activity GO:0044024 IEA
    histone H2BS14 kinase activity GO:0044025 IEA
    histone H3T3 kinase activity GO:0072354 IEA
    histone H2AS121 kinase activity GO:0072371 IEA
    Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA
    protein serine kinase activity GO:0106310 IEA
    histone H2BS36 kinase activity GO:0140823 IEA
    histone H3S57 kinase activity GO:0140855 IEA
    histone H3T45 kinase activity GO:0140857 IEA
    histone H2AT120 kinase activity GO:1990244 IEA
Biological Process
    MAPK cascade GO:0000165 ISS
    meiotic spindle organization GO:0000212 ISS
    oocyte maturation GO:0001556 IMP
    chromatin organization GO:0006325 ISS
    chromatin remodeling GO:0006338 IEA
    signal transduction GO:0007165 IBA
    regulation of meiotic nuclear division GO:0040020 IEA
    positive regulation of MAPK cascade GO:0043410 IBA
    positive regulation of MAPK cascade GO:0043410 ISS
    protein autophosphorylation GO:0046777 ISS
    establishment of meiotic spindle orientation GO:0051296 ISS
    positive regulation of ERK1 and ERK2 cascade GO:0070374 IDA
    negative regulation of metaphase/anaphase transition of meiotic cell cycle GO:1902103 IBA
    negative regulation of metaphase/anaphase transition of meiotic cell cycle GO:1902103 ISS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IMP
    cytosol GO:0005829 ISS
 Experiment description of studies that identified MOS in exosomes
1
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for MOS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NOTCH2NL 388677
Two-hybrid Homo sapiens
2 HOMER3 9454
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 MAP2K2 5605
Two-hybrid Homo sapiens
4 LYPD3 27076
Affinity Capture-MS Homo sapiens
5 CCNDBP1 23582
Two-hybrid Homo sapiens
6 TP53BP2  
Two-hybrid Homo sapiens
7 ZBTB2 57621
Two-hybrid Homo sapiens
8 RHOU 58480
Reconstituted Complex Homo sapiens
9 STK25 10494
Affinity Capture-MS Homo sapiens
10 TRAF2 7186
Two-hybrid Homo sapiens
11 KRTAP1-3  
Two-hybrid Homo sapiens
12 FAM188A 80013
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KCTD6  
Two-hybrid Homo sapiens
14 KRT33B 3884
Two-hybrid Homo sapiens
15 HOMEZ  
Two-hybrid Homo sapiens
16 KIFC3 3801
Two-hybrid Homo sapiens
17 GOLGA6L9  
Two-hybrid Homo sapiens
18 SPERT  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
19 KRT34  
Two-hybrid Homo sapiens
20 GFAP 2670
Two-hybrid Homo sapiens
21 NBPF19  
Two-hybrid Homo sapiens
22 ASB6 140459
Two-hybrid Homo sapiens
23 GOLGA6A  
Two-hybrid Homo sapiens
24 CLUH 23277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 ATRIP  
Two-hybrid Homo sapiens
26 PSTPIP1 9051
Two-hybrid Homo sapiens
27 STK26 51765
Affinity Capture-MS Homo sapiens
28 HSP90AA1 3320
Affinity Capture-Luminescence Homo sapiens
29 IKZF1  
Two-hybrid Homo sapiens
30 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 CCDC102B  
Two-hybrid Homo sapiens
32 MTMR9 66036
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
33 KRT27 342574
Two-hybrid Homo sapiens
34 MYOD1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
35 GOLGA2 2801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
36 LZTS2 84445
Two-hybrid Homo sapiens
37 KRT15 3866
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 BIRC6 57448
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 HSP90AA4P 3323
Affinity Capture-MS Homo sapiens
40 DYDC1  
Two-hybrid Homo sapiens
41 HECW2  
Affinity Capture-MS Homo sapiens
42 PPP2R5E 5529
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 TRIM27  
Two-hybrid Homo sapiens
44 KRT13 3860
Two-hybrid Homo sapiens
45 SEC24C 9632
Two-hybrid Homo sapiens
46 MEOX2  
Two-hybrid Homo sapiens
47 ACTN2 88
Two-hybrid Homo sapiens
48 KRT40  
Two-hybrid Homo sapiens
49 DZIP1  
Two-hybrid Homo sapiens
50 BICD2 23299
Two-hybrid Homo sapiens
51 USHBP1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
52 MIPOL1  
Two-hybrid Homo sapiens
53 CALCOCO2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 PPP2R5A 5525
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 MTUS2 23281
Two-hybrid Homo sapiens
56 CCDC33 80125
Two-hybrid Homo sapiens
57 CCDC136  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 MID2 11043
Two-hybrid Homo sapiens
59 C17orf59 54785
Two-hybrid Homo sapiens
60 TRAF1 7185
Two-hybrid Homo sapiens
61 SSX2IP  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MOS is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here