Gene description for MID2
Gene name midline 2
Gene symbol MID2
Other names/aliases FXY2
MRX101
RNF60
TRIM1
Species Homo sapiens
 Database cross references - MID2
ExoCarta ExoCarta_11043
Vesiclepedia VP_11043
Entrez Gene 11043
HGNC 7096
MIM 300204
UniProt Q9UJV3  
 MID2 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for MID2
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    microtubule binding GO:0008017 IMP
    zinc ion binding GO:0008270 IEA
    transferase activity GO:0016740 IEA
    enzyme binding GO:0019899 IPI
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
    phosphoprotein binding GO:0051219 IPI
Biological Process
    positive regulation of autophagy GO:0010508 IMP
    protein ubiquitination GO:0016567 IEA
    negative regulation of viral transcription GO:0032897 IDA
    protein localization to microtubule GO:0035372 IBA
    protein localization to microtubule GO:0035372 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    suppression of viral release by host GO:0044790 IDA
    innate immune response GO:0045087 IDA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    negative regulation of viral entry into host cell GO:0046597 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IMP
    positive regulation of NF-kappaB transcription factor activity GO:0051092 IMP
Subcellular Localization
    cytoplasm GO:0005737 IEA
    microtubule GO:0005874 IBA
    microtubule GO:0005874 IDA
    microtubule GO:0005874 IDA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified MID2 in exosomes
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for MID2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MVP 9961
Two-hybrid Homo sapiens
2 CEP57L1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 ZNF24  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 GMNN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LGALS14  
Two-hybrid Homo sapiens
6 KIFC3 3801
Two-hybrid Homo sapiens
7 SCNM1  
Two-hybrid Homo sapiens
8 MID1IP1  
Two-hybrid Homo sapiens
9 BRCA1 672
Two-hybrid Homo sapiens
10 BYSL 705
Two-hybrid Homo sapiens
11 SLC25A48  
Two-hybrid Homo sapiens
12 PRPF3  
Two-hybrid Homo sapiens
13 MID1 4281
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
14 DIEXF  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
15 STX11 8676
Two-hybrid Homo sapiens
16 TRIM54  
Two-hybrid Homo sapiens
17 TCEB3 6924
Two-hybrid Homo sapiens
18 HOXB9  
Two-hybrid Homo sapiens
19 UBE2E2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
20 ZNF440  
Two-hybrid Homo sapiens
21 LENG1  
Two-hybrid Homo sapiens
22 PPP1R18 170954
Two-hybrid Homo sapiens
23 MAGOHB 55110
Two-hybrid Homo sapiens
24 ZGPAT  
Two-hybrid Homo sapiens
25 CALCOCO2  
Two-hybrid Homo sapiens
26 CTSZ 1522
Two-hybrid Homo sapiens
27 PSMC2 5701
Affinity Capture-MS Homo sapiens
28 MID2 11043
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
29 DGCR6L  
Two-hybrid Homo sapiens
30 OTUB2  
Two-hybrid Homo sapiens
31 SDCBP 6386
Two-hybrid Homo sapiens
32 FBF1  
Two-hybrid Homo sapiens
33 RCOR3  
Two-hybrid Homo sapiens
34 GFI1B  
Two-hybrid Homo sapiens
35 RPH3AL 9501
Two-hybrid Homo sapiens
36 UNC45A 55898
Two-hybrid Homo sapiens
37 ADAMTSL4  
Two-hybrid Homo sapiens
38 AEN  
Two-hybrid Homo sapiens
39 SPAG5 10615
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
40 UBE2E3 10477
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
41 AQP1 358
Two-hybrid Homo sapiens
42 TMEM14B  
Two-hybrid Homo sapiens
43 SPATA24  
Two-hybrid Homo sapiens
44 TOP3B 8940
Two-hybrid Homo sapiens
45 ISCU 23479
Two-hybrid Homo sapiens
46 MOS 4342
Two-hybrid Homo sapiens
47 UBE2D4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
48 TCEA2  
Two-hybrid Homo sapiens
49 TRIM42  
Two-hybrid Homo sapiens
50 PSMD11 5717
Affinity Capture-MS Homo sapiens
51 GOLGA2 2801
Two-hybrid Homo sapiens
52 SNAP47 116841
Two-hybrid Homo sapiens
53 FAM107A  
Two-hybrid Homo sapiens
54 KIAA1683  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
55 TSGA10  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
56 PSMD2 5708
Affinity Capture-MS Homo sapiens
57 DGCR6  
Two-hybrid Homo sapiens
58 PTCD2  
Two-hybrid Homo sapiens
59 GORASP2 26003
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
60 FRMD6 122786
Two-hybrid Homo sapiens
61 DYDC1  
Two-hybrid Homo sapiens
62 TUBA1B 10376
Affinity Capture-MS Homo sapiens
63 UBE2D3 7323
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
64 PRPF31 26121
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
65 IGBP1 3476
Co-localization Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
66 TRPV6  
Two-hybrid Homo sapiens
67 CEP128  
Affinity Capture-MS Homo sapiens
68 UBE2N 7334
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
69 TUBB 203068
Affinity Capture-MS Homo sapiens
70 COX5B 1329
Two-hybrid Homo sapiens
71 FAM214A  
Two-hybrid Homo sapiens
72 CDKN2AIP  
Affinity Capture-MS Homo sapiens
73 CBX8 57332
Two-hybrid Homo sapiens
74 ZBTB24  
Two-hybrid Homo sapiens
75 CCDC120  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
76 ZNF564  
Two-hybrid Homo sapiens
77 ZFYVE21  
Two-hybrid Homo sapiens
78 ASPM 259266
Affinity Capture-MS Homo sapiens
79 C19orf66  
Two-hybrid Homo sapiens
80 CUL3 8452
Affinity Capture-MS Homo sapiens
81 TUBB4B 10383
Affinity Capture-MS Homo sapiens
82 UBE2E1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
83 ZNF250  
Two-hybrid Homo sapiens
84 ATRIP  
Two-hybrid Homo sapiens
85 TFPT  
Affinity Capture-MS Homo sapiens
86 FAM90A1  
Two-hybrid Homo sapiens
87 CCDC42  
Two-hybrid Homo sapiens
88 SERINC5 256987
Affinity Capture-MS Homo sapiens
89 BRMS1L  
Two-hybrid Homo sapiens
90 FBXL18 80028
Two-hybrid Homo sapiens
91 NXF1 10482
Two-hybrid Homo sapiens
92 WT1-AS  
Two-hybrid Homo sapiens
93 SYT17  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
94 UBE2D2 7322
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
95 TRIM32 22954
Two-hybrid Homo sapiens
96 MFAP1  
Two-hybrid Homo sapiens
97 EPN3 55040
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 BCL6B  
Two-hybrid Homo sapiens
99 TRIM27  
Two-hybrid Homo sapiens
100 UBTD1 80019
Two-hybrid Homo sapiens
101 Igbp1  
Two-hybrid Mus musculus
Two-hybrid Mus musculus
102 ZNF587  
Two-hybrid Homo sapiens
103 PSMB5 5693
Affinity Capture-MS Homo sapiens
104 DCX  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 LGALS8 3964
Two-hybrid Homo sapiens
106 GMCL1  
Two-hybrid Homo sapiens
107 ZC2HC1C  
Two-hybrid Homo sapiens
108 ZNF417  
Two-hybrid Homo sapiens
109 UBXN1 51035
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
110 UBE2U  
Two-hybrid Homo sapiens
111 GSTT1 2952
Affinity Capture-MS Homo sapiens
112 UBE2D1 7321
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
113 HIF1A 3091
Affinity Capture-MS Homo sapiens
114 KIF1A 547
Two-hybrid Homo sapiens
115 PPP4C 5531
Affinity Capture-MS Homo sapiens
116 ZNF785  
Two-hybrid Homo sapiens
117 SLC25A6 293
Two-hybrid Homo sapiens
118 SPRY2 10253
Two-hybrid Homo sapiens
119 SNAI1  
Two-hybrid Homo sapiens
120 CCHCR1  
Two-hybrid Homo sapiens
121 RPP25L  
Two-hybrid Homo sapiens
122 UTP23  
Two-hybrid Homo sapiens
123 ZSCAN12  
Two-hybrid Homo sapiens
124 RUNX1T1  
Two-hybrid Homo sapiens
125 CHD2 1106
Two-hybrid Homo sapiens
126 ZNF792 126375
Two-hybrid Homo sapiens
127 PSMA1 5682
Two-hybrid Homo sapiens
128 THAP7  
Two-hybrid Homo sapiens
129 LRRK2 120892
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
130 FAM161A  
Two-hybrid Homo sapiens
131 FARS2 10667
Two-hybrid Homo sapiens
132 JOSD1  
Two-hybrid Homo sapiens
133 TCAF1 9747
Two-hybrid Homo sapiens
134 KXD1 79036
Affinity Capture-MS Homo sapiens
135 METTL17  
Two-hybrid Homo sapiens
136 TRIM29 23650
Two-hybrid Homo sapiens
137 SPG21 51324
Two-hybrid Homo sapiens
138 ZNF774  
Two-hybrid Homo sapiens
139 NR1D2  
Two-hybrid Homo sapiens
140 ZNF165  
Two-hybrid Homo sapiens
141 PSMD3 5709
Affinity Capture-MS Homo sapiens
142 DMRT3  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which MID2 is involved
No pathways found





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