Gene description for RPH3AL
Gene name rabphilin 3A-like (without C2 domains)
Gene symbol RPH3AL
Other names/aliases NOC2
Species Homo sapiens
 Database cross references - RPH3AL
ExoCarta ExoCarta_9501
Entrez Gene 9501
HGNC 10296
MIM 604881
UniProt Q9UNE2  
 RPH3AL identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for RPH3AL
Molecular Function
    LIM domain binding GO:0030274 IEA
    clathrin binding GO:0030276 IBA
    protein binding GO:0005515 IPI
    Rab GTPase binding GO:0017137 IEA
    calcium ion binding GO:0005509 IBA
    cytoskeletal protein binding GO:0008092 TAS
    syntaxin binding GO:0019905 IBA
    calcium-dependent phospholipid binding GO:0005544 IBA
Biological Process
    regulation of calcium ion-dependent exocytosis GO:0017158 IBA
    negative regulation of G-protein coupled receptor protein signaling pathway GO:0045744 IEA
    positive regulation of protein secretion GO:0050714 IEA
    exocytosis GO:0006887 TAS
    glucose homeostasis GO:0042593 IEA
    synaptic vesicle exocytosis GO:0016079 IBA
    response to drug GO:0042493 IEA
    calcium ion-dependent exocytosis of neurotransmitter GO:0048791 IBA
    intracellular protein transport GO:0006886 IEA
Subcellular Localization
    cytoplasm GO:0005737 TAS
    transport vesicle membrane GO:0030658 IEA
    secretory granule membrane GO:0030667 IEA
    plasma membrane GO:0005886 IBA
 Experiment description of studies that identified RPH3AL in exosomes
Experiment ID 234
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RPH3AL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RAB3B 5865
Affinity Capture-Western Homo sapiens
2 ZYX 7791
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 RAB3GAP1 22930
Reconstituted Complex Homo sapiens
4 RAB8A 4218
Affinity Capture-Western Homo sapiens
5 RAB3A 5864
Affinity Capture-Western Homo sapiens
Invitro Homo sapiens
6 RAB3D 9545
Affinity Capture-Western Homo sapiens
7 UNC13B 10497
Reconstituted Complex Homo sapiens
8 RAB26  
Affinity Capture-Western Homo sapiens
9 RIMS2  
Invivo Homo sapiens
Two-hybrid Homo sapiens
10 RAB27A 5873
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 RAB27B 5874
Affinity Capture-Western Homo sapiens
12 RAB3C 115827
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which RPH3AL is involved
No pathways found

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