Gene description for UNC13B
Gene name unc-13 homolog B (C. elegans)
Gene symbol UNC13B
Other names/aliases MUNC13
Species Homo sapiens
 Database cross references - UNC13B
ExoCarta ExoCarta_10497
Entrez Gene 10497
HGNC 12566
MIM 605836
UniProt O14795  
 UNC13B identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for UNC13B
Molecular Function
    receptor activity GO:0004872 TAS
    protein binding GO:0005515 IPI
    metal ion binding GO:0046872 IEA
    signal transducer activity GO:0004871 TAS
    diacylglycerol binding GO:0019992 IEA
Biological Process
    signal transduction GO:0007165 TAS
    synaptic vesicle docking GO:0016081 IEA
    synaptic vesicle priming GO:0016082 ISS
    synaptic transmission GO:0007268 TAS
    neurotransmitter secretion GO:0007269 TAS
    apoptotic process GO:0006915 TAS
    innervation GO:0060384 IEA
    positive regulation of synaptic vesicle priming GO:0010808 ISS
    regulation of short-term neuronal synaptic plasticity GO:0048172 IEA
    excretion GO:0007588 TAS
    neuromuscular junction development GO:0007528 IEA
    positive regulation of inhibitory postsynaptic membrane potential GO:0097151 ISS
    glutamate secretion GO:0014047 TAS
    intracellular signal transduction GO:0035556 IEA
    synaptic transmission, glutamatergic GO:0035249 IEA
Subcellular Localization
    cytoplasm GO:0005737 TAS
    cytosol GO:0005829 TAS
    terminal bouton GO:0043195 ISS
    presynaptic active zone GO:0048786 TAS
    cell junction GO:0030054 IEA
    plasma membrane GO:0005886 ISS
    neuromuscular junction GO:0031594 IEA
    Golgi apparatus GO:0005794 IDA
 Experiment description of studies that identified UNC13B in exosomes
Experiment ID 126
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for UNC13B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 STX1B 112755
Two-hybrid Homo sapiens
2 DOC2B  
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
3 STX1A 6804
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 RPH3AL 9501
Reconstituted Complex Homo sapiens
5 RIMS1  
Invivo Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
6 DOC2A  
Invitro Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 SPTBN2 6712
Two-hybrid Homo sapiens
View the network image/svg+xml

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