Gene description for DIRAS1
Gene name DIRAS family, GTP-binding RAS-like 1
Gene symbol DIRAS1
Other names/aliases Di-Ras1
GBTS1
RIG
Species Homo sapiens
 Database cross references - DIRAS1
ExoCarta ExoCarta_148252
Entrez Gene 148252
HGNC 19127
MIM 607862
UniProt O95057  
 DIRAS1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DIRAS1
Molecular Function
    GTP binding GO:0005525 IDA
    mitogen-activated protein kinase binding GO:0051019 IPI
    GTPase activity GO:0003924 IDA
Biological Process
    small GTPase mediated signal transduction GO:0007264 IEA
    positive regulation of MAP kinase activity GO:0043406 IDA
    metabolic process GO:0008152 IDA
Subcellular Localization
    intracellular GO:0005622 IEA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified DIRAS1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DIRAS1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DIRAS1 is involved
No pathways found





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