Gene description for GBA3
Gene name glucosidase, beta, acid 3 (gene/pseudogene)
Gene symbol GBA3
Other names/aliases CBG
CBGL1
GLUC
KLRP
Species Homo sapiens
 Database cross references - GBA3
ExoCarta ExoCarta_57733
Vesiclepedia VP_57733
Entrez Gene 57733
HGNC 19069
MIM 606619
UniProt Q9H227  
 GBA3 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for GBA3
Molecular Function
    galactosylceramidase activity GO:0004336 IDA
    glucosylceramidase activity GO:0004348 IDA
    glucosylceramidase activity GO:0004348 TAS
    beta-galactosidase activity GO:0004565 IBA
    beta-galactosidase activity GO:0004565 IDA
    protein binding GO:0005515 IPI
    beta-glucosidase activity GO:0008422 IDA
    glycosylceramidase activity GO:0017042 IBA
    glycosylceramidase activity GO:0017042 IDA
Biological Process
    glucosylceramide catabolic process GO:0006680 IDA
    glucosylceramide catabolic process GO:0006680 IDA
    glucosylceramide catabolic process GO:0006680 IMP
    galactosylceramide catabolic process GO:0006683 IDA
    oligosaccharide catabolic process GO:0009313 IDA
    glycoside catabolic process GO:0016139 IDA
    glycosylceramide catabolic process GO:0046477 IBA
    glycosphingolipid catabolic process GO:0046479 TAS
    protein stabilization GO:0050821 IDA
    beta-glucoside catabolic process GO:1901805 IDA
    positive regulation of exo-alpha-sialidase activity GO:1903017 IDA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    membrane GO:0016020 IEA
    catalytic complex GO:1902494 IDA
 Experiment description of studies that identified GBA3 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for GBA3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PDCL 5082
Affinity Capture-MS Homo sapiens
2 PRKCSH 5589
Two-hybrid Homo sapiens
3 RAP1GDS1 5910
Affinity Capture-MS Homo sapiens
4 KIF20A 10112
Affinity Capture-MS Homo sapiens
5 DIRAS1 148252
Affinity Capture-MS Homo sapiens
6 CCT4 10575
Affinity Capture-MS Homo sapiens
7 KIF14 9928
Affinity Capture-MS Homo sapiens
8 CCT2 10576
Affinity Capture-MS Homo sapiens
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