Gene description for ARL4C
Gene name ADP-ribosylation factor-like 4C
Gene symbol ARL4C
Other names/aliases ARL7
LAK
Species Homo sapiens
 Database cross references - ARL4C
ExoCarta ExoCarta_10123
Entrez Gene 10123
HGNC 698
MIM 604787
UniProt P56559  
 ARL4C identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ARL4C
Molecular Function
    GTP binding GO:0005525 IEA
    protein binding GO:0005515 IPI
    alpha-tubulin binding GO:0043014 IDA
    GTPase activity GO:0003924 TAS
Biological Process
    metabolic process GO:0008152 TAS
    small GTPase mediated signal transduction GO:0007264 IEA
    endocytic recycling GO:0032456 IDA
Subcellular Localization
    filopodium GO:0030175 IEA
    nucleus GO:0005634 TAS
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified ARL4C in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ARL4C
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ARL4C is involved
No pathways found





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