Gene description for UNC13A
Gene name unc-13 homolog A (C. elegans)
Gene symbol UNC13A
Other names/aliases Munc13-1
Species Homo sapiens
 Database cross references - UNC13A
ExoCarta ExoCarta_23025
Vesiclepedia VP_23025
Entrez Gene 23025
HGNC 23150
MIM 609894
UniProt Q9UPW8  
 UNC13A identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UNC13A
Molecular Function
    metal ion binding GO:0046872 IEA
    diacylglycerol binding GO:0019992 IEA
    protein N-terminus binding GO:0047485 ISS
    syntaxin-1 binding GO:0017075 ISS
Biological Process
    neurotransmitter secretion GO:0007269 ISS
    regulation of synaptic transmission, glutamatergic GO:0051966 TAS
    synaptic vesicle docking GO:0016081 IEA
    synaptic vesicle maturation GO:0016188 IEA
    synaptic transmission, glutamatergic GO:0035249 IEA
    positive regulation of neurotransmitter secretion GO:0001956 IEA
    regulation of short-term neuronal synaptic plasticity GO:0048172 IEA
    positive regulation of dendrite extension GO:1903861 IDA
    innervation GO:0060384 IEA
    intracellular signal transduction GO:0035556 IEA
    neuromuscular junction development GO:0007528 IEA
    beta-amyloid metabolic process GO:0050435 IEA
Subcellular Localization
    cell junction GO:0030054 IEA
    neuron projection GO:0043005 ISS
    presynaptic active zone GO:0048786 TAS
    cytoplasm GO:0005737 IEA
    neuromuscular junction GO:0031594 IEA
    presynaptic membrane GO:0042734 ISS
    axon GO:0030424 IEA
 Experiment description of studies that identified UNC13A in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UNC13A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ERC2 26059
Affinity Capture-Western Homo sapiens
2 BSN  
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which UNC13A is involved
No pathways found





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