Gene description for UNC13A
Gene name unc-13 homolog A (C. elegans)
Gene symbol UNC13A
Other names/aliases Munc13-1
Species Homo sapiens
 Database cross references - UNC13A
ExoCarta ExoCarta_23025
Vesiclepedia VP_23025
Entrez Gene 23025
HGNC 23150
MIM 609894
UniProt Q9UPW8  
 UNC13A identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for UNC13A
Molecular Function
    calcium ion binding GO:0005509 IEA
    calmodulin binding GO:0005516 IBA
    calmodulin binding GO:0005516 ISS
    phospholipid binding GO:0005543 IEA
    syntaxin-1 binding GO:0017075 IBA
    syntaxin-1 binding GO:0017075 ISS
    diacylglycerol binding GO:0019992 IEA
Biological Process
    neurotransmitter secretion GO:0007269 ISS
    synaptic vesicle docking GO:0016081 IBA
    synaptic vesicle priming GO:0016082 IBA
    cell differentiation GO:0030154 IEA
    synaptic transmission, glutamatergic GO:0035249 IBA
    regulation of synaptic transmission, glutamatergic GO:0051966 TAS
    dense core granule priming GO:0061789 IBA
    neuronal dense core vesicle exocytosis GO:0099011 ISS
    presynaptic dense core vesicle exocytosis GO:0099525 IBA
    positive regulation of dendrite extension GO:1903861 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    synaptic vesicle membrane GO:0030672 IBA
    neuromuscular junction GO:0031594 IBA
    presynaptic membrane GO:0042734 IBA
    presynaptic membrane GO:0042734 ISS
    neuron projection GO:0043005 ISS
    terminal bouton GO:0043195 IBA
    presynaptic active zone GO:0048786 TAS
    presynaptic active zone cytoplasmic component GO:0098831 IBA
 Experiment description of studies that identified UNC13A in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for UNC13A
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EPB41L3 23136
Two-hybrid Homo sapiens
2 PRC1 9055
Affinity Capture-MS Homo sapiens
3 Fbxo45  
Affinity Capture-Western Mus musculus
4 MECP2 4204
Affinity Capture-MS Homo sapiens
5 ERC2 26059
Affinity Capture-Western Homo sapiens
6 MOV10 4343
Affinity Capture-RNA Homo sapiens
7 DIRAS1 148252
Affinity Capture-MS Homo sapiens
8 BSN  
Affinity Capture-Western Homo sapiens
9 SHMT2 6472
Affinity Capture-RNA Homo sapiens
10 UBXN10  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which UNC13A is involved
No pathways found





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