Gene description for STX1B
Gene name syntaxin 1B
Gene symbol STX1B
Other names/aliases GEFSP9
STX1B1
STX1B2
Species Homo sapiens
 Database cross references - STX1B
ExoCarta ExoCarta_112755
Vesiclepedia VP_112755
Entrez Gene 112755
HGNC 18539
MIM 601485
UniProt P61266  
 STX1B identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for STX1B
Molecular Function
    SNARE binding GO:0000149 IBA
    signaling receptor binding GO:0005102 IEA
    SNAP receptor activity GO:0005484 IBA
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 ISS
Biological Process
    positive regulation of neurotransmitter secretion GO:0001956 ISS
    intracellular protein transport GO:0006886 IBA
    vesicle docking involved in exocytosis GO:0006904 ISS
    regulation of gene expression GO:0010468 ISS
    regulation of synaptic vesicle priming GO:0010807 ISS
    negative regulation of neuron projection development GO:0010977 ISS
    synaptic vesicle docking GO:0016081 ISS
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IBA
    synaptic vesicle fusion to presynaptic active zone membrane GO:0031629 IEA
    vesicle docking GO:0048278 IBA
    calcium ion-regulated exocytosis of neurotransmitter GO:0048791 IEA
    spontaneous neurotransmitter secretion GO:0061669 IEA
    exocytic insertion of neurotransmitter receptor to postsynaptic membrane GO:0098967 IBA
    negative regulation of synaptic vesicle recycling GO:1903422 IEA
    positive regulation of spontaneous neurotransmitter secretion GO:1904050 IEA
    negative regulation of macropinocytosis GO:1905302 ISS
    positive regulation of excitatory postsynaptic potential GO:2000463 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleus GO:0005634 IEA
    nuclear lamina GO:0005652 IDA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IDA
    centrosome GO:0005813 IEA
    spindle GO:0005819 IEA
    cytosol GO:0005829 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 ISS
    axon GO:0030424 IEA
    SNARE complex GO:0031201 IBA
    neuromuscular junction GO:0031594 IEA
    presynaptic active zone membrane GO:0048787 IBA
    presynaptic active zone membrane GO:0048787 IEA
 Experiment description of studies that identified STX1B in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for STX1B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARMC1 55156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 STXBP1 6812
Reconstituted Complex Homo sapiens
3 GPM6A 2823
Affinity Capture-MS Homo sapiens
4 DNAAF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 HAX1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 KIF20A 10112
Affinity Capture-MS Homo sapiens
7 Htt  
Affinity Capture-MS Mus musculus
8 VAPB 9217
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
9 VAMP2 6844
Two-hybrid Homo sapiens
10 SNAP23 8773
Reconstituted Complex Homo sapiens
11 VAMP1 6843
Two-hybrid Homo sapiens
12 UNC13B 10497
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
13 DGUOK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 NUFIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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