Gene description for FARS2
Gene name phenylalanyl-tRNA synthetase 2, mitochondrial
Gene symbol FARS2
Other names/aliases COXPD14
FARS1
HSPC320
PheRS
dJ520B18.2
Species Homo sapiens
 Database cross references - FARS2
ExoCarta ExoCarta_10667
Entrez Gene 10667
HGNC 21062
MIM 611592
UniProt O95363  
 FARS2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FARS2
Molecular Function
    protein binding GO:0005515 IPI
    tRNA binding GO:0000049 IDA
    ATP binding GO:0005524 IEA
    phenylalanine-tRNA ligase activity GO:0004826 IDA
    magnesium ion binding GO:0000287 IEA
Biological Process
    gene expression GO:0010467 TAS
    tRNA processing GO:0008033 IDA
    phenylalanyl-tRNA aminoacylation GO:0006432 IDA
    tRNA aminoacylation for protein translation GO:0006418 TAS
Subcellular Localization
    cytoplasm GO:0005737 IBA
    mitochondrial matrix GO:0005759 TAS
    mitochondrion GO:0005739 IBA
 Experiment description of studies that identified FARS2 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FARS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FARS2 is involved
PathwayEvidenceSource
Mitochondrial tRNA aminoacylation TAS Reactome





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