Gene description for CDCA4
Gene name cell division cycle associated 4
Gene symbol CDCA4
Other names/aliases HEPP
SEI-3/HEPP
Species Homo sapiens
 Database cross references - CDCA4
ExoCarta ExoCarta_55038
Vesiclepedia VP_55038
Entrez Gene 55038
HGNC 14625
MIM 612270
UniProt Q9BXL8  
 CDCA4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for CDCA4
Molecular Function
    transcription coactivator activity GO:0003713 IBA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of DNA-templated transcription GO:0045893 IEA
Subcellular Localization
    nucleus GO:0005634 IBA
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified CDCA4 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for CDCA4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ENKD1  
Two-hybrid Homo sapiens
2 PTOV1  
Affinity Capture-MS Homo sapiens
3 PPP4C 5531
Affinity Capture-MS Homo sapiens
4 XIAP  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
5 PPP2R2B 5521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 XPO1 7514
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
7 CPNE7 27132
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 FARS2 10667
Two-hybrid Homo sapiens
9 KAT2B  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
10 FAM222B  
Two-hybrid Homo sapiens
11 SEPHS1 22929
Two-hybrid Homo sapiens
12 NMNAT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 PRMT6  
Two-hybrid Homo sapiens
14 MKRN3  
Two-hybrid Homo sapiens
15 BFSP2  
Two-hybrid Homo sapiens
16 PPP2R2C 5522
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 ZNF451 26036
Two-hybrid Homo sapiens
18 SUPT7L  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
19 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
20 MAP2K6 5608
Affinity Capture-MS Homo sapiens
21 KDM1A 23028
Two-hybrid Homo sapiens
22 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 TRIM28 10155
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
24 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 PARD6B 84612
Two-hybrid Homo sapiens
26 SUV39H2 79723
Two-hybrid Homo sapiens
27 C1orf109  
Two-hybrid Homo sapiens
28 ZNF547  
Affinity Capture-MS Homo sapiens
29 PPP2CA 5515
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SUV39H1  
Two-hybrid Homo sapiens
31 HNRNPU 3192
Affinity Capture-MS Homo sapiens
32 SHC3  
Two-hybrid Homo sapiens
33 PPP2R2A 5520
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 C20orf195  
Two-hybrid Homo sapiens
36 PPP2CB 5516
Affinity Capture-MS Homo sapiens
37 BDH2 56898
Affinity Capture-MS Homo sapiens
38 TCAP  
Two-hybrid Homo sapiens
39 SUOX  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CDCA4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here