Gene description for PPP2R2C
Gene name protein phosphatase 2, regulatory subunit B, gamma
Gene symbol PPP2R2C
Other names/aliases B55-GAMMA
Species Homo sapiens
 Database cross references - PPP2R2C
ExoCarta ExoCarta_5522
Entrez Gene 5522
HGNC 9306
MIM 605997
UniProt Q9Y2T4  
 PPP2R2C identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells 20124223    
 Gene ontology annotations for PPP2R2C
Molecular Function
    protein phosphatase type 2A regulator activity GO:0008601 NAS
    protein binding GO:0005515 IPI
Biological Process
    regulation of protein phosphatase type 2A activity GO:0034047 NAS
    signal transduction GO:0007165 IEA
Subcellular Localization
    protein phosphatase type 2A complex GO:0000159 NAS
 Experiment description of studies that identified PPP2R2C in exosomes
Experiment ID 191
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 20124223    
Organism Homo sapiens
Experiment description Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.
Authors Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.
Journal name Mol Cell Proteomics
Publication year 2010
Sample Squamous carcinoma cells
Sample name Squamous carcinoma cell (A431)
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PPP2R2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PPP2CA 5515
Affinity Capture-MS Homo sapiens
2 CCT7 10574
Affinity Capture-MS Homo sapiens
3 CCT6A 908
Affinity Capture-MS Homo sapiens
4 CCT5 22948
Affinity Capture-MS Homo sapiens
5 ARL2 402
Co-purification Homo sapiens
6 PPP2R1B 5519
Affinity Capture-MS Homo sapiens
7 CCT8 10694
Affinity Capture-MS Homo sapiens
8 CCT3 7203
Affinity Capture-MS Homo sapiens
9 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
10 CCT4 10575
Affinity Capture-MS Homo sapiens
11 TCP1 6950
Affinity Capture-MS Homo sapiens
12 CCT2 10576
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPP2R2C is involved
No pathways found

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