Gene description for ARL2
Gene name ADP-ribosylation factor-like 2
Gene symbol ARL2
Other names/aliases ARFL2
Species Homo sapiens
 Database cross references - ARL2
ExoCarta ExoCarta_402
Entrez Gene 402
HGNC 693
MIM 601175
UniProt P36404  
 ARL2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for ARL2
Molecular Function
    GTPase inhibitor activity GO:0005095 TAS
    GTP binding GO:0005525 IMP
    protein binding GO:0005515 IPI
    GTPase activity GO:0003924 IMP
Biological Process
    positive regulation of microtubule polymerization GO:0031116 IDA
    regulation of insulin secretion GO:0050796 TAS
    tubulin complex assembly GO:0007021 TAS
    energy reserve metabolic process GO:0006112 TAS
    bicellular tight junction assembly GO:0070830 ISS
    negative regulation of GTPase activity GO:0034260 IDA
    small GTPase mediated signal transduction GO:0007264 IEA
    regulation of microtubule polymerization GO:0031113 IMP
    small molecule metabolic process GO:0044281 TAS
    cell cycle GO:0007049 IEA
    positive regulation of cell-substrate adhesion GO:0010811 ISS
    maintenance of protein location in nucleus GO:0051457 IDA
    centrosome organization GO:0051297 IMP
Subcellular Localization
    mitochondrial matrix GO:0005759 TAS
    extracellular exosome GO:0070062 IDA
    lateral plasma membrane GO:0016328 ISS
    centrosome GO:0005813 IDA
    nucleus GO:0005634 IDA
    cytosol GO:0005829 TAS
    primary cilium GO:0072372 IDA
    mitochondrial intermembrane space GO:0005758 IDA
 Experiment description of studies that identified ARL2 in exosomes
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for ARL2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TBCD 6904
Invivo Homo sapiens
Invitro Homo sapiens
Co-purification Homo sapiens
2 PPP2CA 5515
Co-purification Homo sapiens
3 PPP2R5D  
Co-purification Homo sapiens
4 PPP2R2C 5522
Co-purification Homo sapiens
5 UNC119  
Invitro Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
6 PPP2CB 5516
Co-purification Homo sapiens
7 ARL2BP  
Co-fractionation Homo sapiens
8 PDE6D  
Co-crystal Structure Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ARL2 is involved
Post-chaperonin tubulin folding pathway IEA Reactome
Regulation of insulin secretion TAS Reactome

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