Gene description for DPH2
Gene name DPH2 homolog (S. cerevisiae)
Gene symbol DPH2
Other names/aliases DPH2L2
Species Homo sapiens
 Database cross references - DPH2
ExoCarta ExoCarta_1802
Entrez Gene 1802
HGNC 3004
MIM 603456
UniProt Q9BQC3  
 DPH2 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for DPH2
Molecular Function
    protein binding GO:0005515 IPI
    2-(3-amino-3-carboxypropyl)histidine synthase activity GO:0090560 EXP
Biological Process
    post-translational protein modification GO:0043687 TAS
    cellular protein metabolic process GO:0044267 TAS
    peptidyl-diphthamide biosynthetic process from peptidyl-histidine GO:0017183 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DPH2 in exosomes
1
Experiment ID 237
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✔
HSP90B1
EV Negative markers
✔
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for DPH2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which DPH2 is involved
PathwayEvidenceSource
Synthesis of diphthamide-EEF2 TAS Reactome





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