Gene description for FOXF1
Gene name forkhead box F1
Gene symbol FOXF1
Other names/aliases ACDMPV
FKHL5
FREAC1
Species Homo sapiens
 Database cross references - FOXF1
ExoCarta ExoCarta_2294
Vesiclepedia VP_2294
Entrez Gene 2294
HGNC 3809
MIM 601089
UniProt Q12946  
 FOXF1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FOXF1
Molecular Function
    RNA polymerase II transcription regulatory region sequence-specific DNA binding GO:0000977 IMP
    RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0000978 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription activator activity, RNA polymerase II-specific GO:0001228 IMP
    DNA binding GO:0003677 IDA
    sequence-specific DNA binding GO:0043565 ISS
Biological Process
    negative regulation of transcription by RNA polymerase II GO:0000122 IEA
    blood vessel development GO:0001568 IMP
    vasculogenesis GO:0001570 IEA
    in utero embryonic development GO:0001701 IMP
    somitogenesis GO:0001756 IEA
    morphogenesis of a branching structure GO:0001763 IMP
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    endocardial cushion development GO:0003197 IMP
    cardiac left ventricle morphogenesis GO:0003214 IMP
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    smoothened signaling pathway GO:0007224 IEA
    determination of left/right symmetry GO:0007368 IEA
    midgut development GO:0007494 IMP
    heart development GO:0007507 IMP
    animal organ morphogenesis GO:0009887 IBA
    positive regulation of cell-substrate adhesion GO:0010811 IEA
    detection of wounding GO:0014822 IEA
    extracellular matrix organization GO:0030198 IEA
    respiratory tube development GO:0030323 IMP
    lung development GO:0030324 IMP
    positive regulation of cell migration GO:0030335 IEA
    pancreas development GO:0031016 IMP
    negative regulation of mast cell degranulation GO:0043305 IEA
    establishment of epithelial cell apical/basal polarity GO:0045198 IEA
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of transcription by RNA polymerase II GO:0045944 IMP
    lung alveolus development GO:0048286 IEA
    lateral mesodermal cell differentiation GO:0048371 IEA
    embryonic digestive tract morphogenesis GO:0048557 IMP
    digestive tract development GO:0048565 IMP
    embryonic ectodermal digestive tract morphogenesis GO:0048613 IMP
    embryonic foregut morphogenesis GO:0048617 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    smooth muscle cell differentiation GO:0051145 IEA
    lung vasculature development GO:0060426 IMP
    trachea development GO:0060438 IMP
    epithelial tube branching involved in lung morphogenesis GO:0060441 IEA
    right lung morphogenesis GO:0060461 IEA
    lung lobe morphogenesis GO:0060463 IEA
    venous blood vessel development GO:0060841 IMP
    epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 IEA
    cellular response to cytokine stimulus GO:0071345 IEA
    cellular response to organic cyclic compound GO:0071407 IEA
    ureter development GO:0072189 IMP
    mesenchyme migration GO:0090131 IEA
    ductus arteriosus closure GO:0097070 IMP
    cell-cell adhesion GO:0098609 IEA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IC
    transcription regulator complex GO:0005667 TAS
 Experiment description of studies that identified FOXF1 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FOXF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAGEA8  
Affinity Capture-MS Homo sapiens
2 FOXF1 2294
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 FOXF2  
Affinity Capture-MS Homo sapiens
4 DKK3 27122
Affinity Capture-MS Homo sapiens
5 APLNR  
Affinity Capture-MS Homo sapiens
6 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
7 KHSRP 8570
Affinity Capture-MS Homo sapiens
8 ICAM1 3383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 FOXP1 27086
Affinity Capture-MS Homo sapiens
10 HOXD13  
Affinity Capture-MS Homo sapiens
11 AURKA 6790
Reconstituted Complex Homo sapiens
12 HOXB13  
Affinity Capture-MS Homo sapiens
13 PRG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 PRSS50  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 FUBP3 8939
Affinity Capture-MS Homo sapiens
16 HNRNPCL2 440563
Affinity Capture-MS Homo sapiens
17 CPS1 1373
Affinity Capture-MS Homo sapiens
18 SATB2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 FANCM 57697
Affinity Capture-Western Homo sapiens
20 HOXB9  
Affinity Capture-MS Homo sapiens
21 GAPVD1 26130
Affinity Capture-MS Homo sapiens
22 FBLN5 10516
Affinity Capture-MS Homo sapiens
23 LRP1 4035
Affinity Capture-MS Homo sapiens
24 FLNC 2318
Affinity Capture-MS Homo sapiens
25 PUSL1  
Affinity Capture-MS Homo sapiens
26 CPA5  
Affinity Capture-MS Homo sapiens
27 RAD54L2  
Affinity Capture-MS Homo sapiens
28 SDF4 51150
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 STRBP 55342
Affinity Capture-MS Homo sapiens
30 SATB1 6304
Affinity Capture-MS Homo sapiens
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