Gene description for FOXF1
Gene name forkhead box F1
Gene symbol FOXF1
Other names/aliases ACDMPV
FKHL5
FREAC1
Species Homo sapiens
 Database cross references - FOXF1
ExoCarta ExoCarta_2294
Entrez Gene 2294
HGNC 3809
MIM 601089
UniProt Q12946  
 FOXF1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for FOXF1
Molecular Function
    RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity GO:0003705 IBA
    sequence-specific DNA binding GO:0043565 ISS
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001228 IMP
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IMP
    DNA binding GO:0003677 IDA
Biological Process
    smooth muscle cell differentiation GO:0051145 IEA
    positive regulation of cell-substrate adhesion GO:0010811 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IMP
    branching involved in open tracheal system development GO:0060446 IMP
    trachea development GO:0060438 IEA
    pancreas development GO:0031016 IMP
    vasculogenesis GO:0001570 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    lung development GO:0030324 IMP
    epithelial cell differentiation involved in mammary gland alveolus development GO:0061030 IEA
    lung alveolus development GO:0048286 IEA
    positive regulation of mesenchymal cell proliferation GO:0002053 IEA
    endocardial cushion development GO:0003197 IMP
    blood vessel development GO:0001568 IMP
    positive regulation of cell migration GO:0030335 IEA
    cardiac left ventricle morphogenesis GO:0003214 IMP
    embryonic foregut morphogenesis GO:0048617 IEA
    respiratory tube development GO:0030323 IMP
    detection of wounding GO:0014822 IEA
    heart development GO:0007507 IMP
    midgut development GO:0007494 IMP
    embryonic ectodermal digestive tract morphogenesis GO:0048613 IMP
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    ureter development GO:0072189 IMP
    in utero embryonic development GO:0001701 IMP
    transcription from RNA polymerase II promoter GO:0006366 IBA
    venous blood vessel development GO:0060841 IMP
    lateral mesodermal cell differentiation GO:0048371 IEA
    extracellular matrix organization GO:0030198 IEA
    epithelial tube branching involved in lung morphogenesis GO:0060441 IEA
    smoothened signaling pathway GO:0007224 IEA
    cellular response to cytokine stimulus GO:0071345 IEA
    negative regulation of inflammatory response GO:0050728 IEA
    single organismal cell-cell adhesion GO:0016337 IEA
    regulation of smooth muscle cell differentiation GO:0051150 IEA
    ductus arteriosus closure GO:0097070 IMP
    determination of left/right symmetry GO:0007368 IEA
    right lung morphogenesis GO:0060461 IEA
    lung vasculature development GO:0060426 IMP
    renal system development GO:0072001 IMP
    somitogenesis GO:0001756 IEA
    lung lobe morphogenesis GO:0060463 IEA
    establishment of epithelial cell apical/basal polarity GO:0045198 IEA
    cell differentiation GO:0030154 IBA
    mesenchyme migration GO:0090131 IEA
    digestive tract development GO:0048565 IMP
    morphogenesis of a branching structure GO:0001763 IMP
    cellular response to organic cyclic compound GO:0071407 IEA
    negative regulation of mast cell degranulation GO:0043305 IEA
    embryonic digestive tract morphogenesis GO:0048557 IMP
Subcellular Localization
    transcription factor complex GO:0005667 TAS
    nucleus GO:0005634 IC
 Experiment description of studies that identified FOXF1 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for FOXF1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which FOXF1 is involved
No pathways found





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