Gene description for ELP2
Gene name elongator acetyltransferase complex subunit 2
Gene symbol ELP2
Other names/aliases SHINC-2
Species Homo sapiens
 Database cross references - ELP2
ExoCarta ExoCarta_55250
Entrez Gene 55250
HGNC 18248
MIM 616054
UniProt Q6IA86  
 ELP2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for ELP2
Molecular Function
    RNA polymerase II core binding GO:0000993 IDA
    protein kinase binding GO:0019901 IEA
Biological Process
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    regulation of transcription from RNA polymerase II promoter GO:0006357 TAS
    regulation of JAK-STAT cascade GO:0046425 IEA
    chromatin organization GO:0006325 TAS
Subcellular Localization
    cytoplasm GO:0005737 NAS
    histone acetyltransferase complex GO:0000123 IDA
    Elongator holoenzyme complex GO:0033588 IDA
    transcription elongation factor complex GO:0008023 IDA
 Experiment description of studies that identified ELP2 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ELP2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IKBKAP 8518
Co-purification Homo sapiens
2 STAT3 6774
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 STAT1 6772
Reconstituted Complex Homo sapiens
4 JAK2 3717
Affinity Capture-Western Homo sapiens
5 JAK1 3716
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
6 TYK2 7297
Affinity Capture-Western Homo sapiens
7 STAT5B 6777
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which ELP2 is involved
HATs acetylate histones TAS Reactome

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