Gene description for ELP6
Gene name elongator acetyltransferase complex subunit 6
Gene symbol ELP6
Other names/aliases C3orf75
TMEM103
Species Homo sapiens
 Database cross references - ELP6
ExoCarta ExoCarta_54859
Vesiclepedia VP_54859
Entrez Gene 54859
HGNC 25976
MIM 615020
UniProt Q0PNE2  
 ELP6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ELP6
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    tRNA wobble uridine modification GO:0002098 NAS
    regulation of translation GO:0006417 NAS
    positive regulation of cell migration GO:0030335 ISS
Subcellular Localization
    nucleus GO:0005634 IDA
    cytosol GO:0005829 IDA
    elongator holoenzyme complex GO:0033588 IBA
    elongator holoenzyme complex GO:0033588 IDA
    elongator holoenzyme complex GO:0033588 IPI
 Experiment description of studies that identified ELP6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ELP6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PSMA6 5687
Co-fractionation Homo sapiens
2 IKBKAP 8518
Affinity Capture-Western Homo sapiens
3 KLHL15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 POLR2C 5432
Proximity Label-MS Homo sapiens
5 PSMA3 5684
Co-fractionation Homo sapiens
6 PSMB3 5691
Co-fractionation Homo sapiens
7 FBXL6  
Proximity Label-MS Homo sapiens
8 EGFR 1956
Negative Genetic Homo sapiens
9 CIAO1 9391
Affinity Capture-MS Homo sapiens
10 PSMA4 5685
Co-fractionation Homo sapiens
11 LAMP1 3916
Affinity Capture-MS Homo sapiens
12 ELP3 55140
Affinity Capture-MS Homo sapiens
13 ANKRD40 91369
Co-fractionation Homo sapiens
14 PSMA2 5683
Co-fractionation Homo sapiens
15 PDDC1 347862
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 MLH1 4292
Two-hybrid Homo sapiens
17 CLTB 1212
Proximity Label-MS Homo sapiens
18 PSMB8 5696
Co-fractionation Homo sapiens
19 FAM96B 51647
Affinity Capture-MS Homo sapiens
20 IWS1  
Co-fractionation Homo sapiens
21 ZBTB2 57621
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 ZNF639  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 PXN 5829
Proximity Label-MS Homo sapiens
24 DYNLRB1 83658
Proximity Label-MS Homo sapiens
25 ZBTB25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 PIPOX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PSMC5 5705
Co-fractionation Homo sapiens
28 PSMB5 5693
Co-fractionation Homo sapiens
29 ELP5 23587
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 KRAS 3845
Negative Genetic Homo sapiens
31 APBA1  
Affinity Capture-MS Homo sapiens
32 PSMB6 5694
Co-fractionation Homo sapiens
33 PSMC4 5704
Co-fractionation Homo sapiens
34 NELFB 25920
Co-fractionation Homo sapiens
35 LYPD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 ELP2 55250
Affinity Capture-MS Homo sapiens
37 ELP4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ELP6 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





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