Gene description for MPG
Gene name N-methylpurine-DNA glycosylase
Gene symbol MPG
Other names/aliases AAG
ADPG
APNG
CRA36.1
MDG
Mid1
PIG11
PIG16
anpg
Species Homo sapiens
 Database cross references - MPG
ExoCarta ExoCarta_4350
Vesiclepedia VP_4350
Entrez Gene 4350
HGNC 7211
MIM 156565
UniProt P29372  
 MPG identified in sEVs derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MPG
Molecular Function
    damaged DNA binding GO:0003684 TAS
    alkylbase DNA N-glycosylase activity GO:0003905 IBA
    protein binding GO:0005515 IPI
    DNA-3-methyladenine glycosylase activity GO:0008725 IEA
    DNA N-glycosylase activity GO:0019104 TAS
    DNA-7-methylguanine glycosylase activity GO:0043916 IEA
    DNA-7-methyladenine glycosylase activity GO:0052821 IEA
    DNA-3-methylguanine glycosylase activity GO:0052822 IEA
    DNA-5-methylcytosine glycosylase activity GO:1990053 IEA
Biological Process
    base-excision repair GO:0006284 IBA
    DNA alkylation repair GO:0006307 TAS
    depurination GO:0045007 TAS
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    mitochondrion GO:0005739 HTP
    cytosol GO:0005829 IDA
    mitochondrial nucleoid GO:0042645 IEA
 Experiment description of studies that identified MPG in sEVs
1
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MPG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HECTD1 25831
Affinity Capture-MS Homo sapiens
2 IKBKAP 8518
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 MECP2 4204
Affinity Capture-MS Homo sapiens
4 Eif3a 13669
Affinity Capture-MS Mus musculus
5 GOT2 2806
Affinity Capture-MS Homo sapiens
6 HSD17B14  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 KBTBD4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 HDGF 3068
Affinity Capture-MS Homo sapiens
9 RAD23A 5886
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
10 KIF14 9928
Affinity Capture-MS Homo sapiens
11 PRNP 5621
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
12 LRRC59 55379
Affinity Capture-MS Homo sapiens
13 RPA2 6118
Affinity Capture-MS Homo sapiens
14 KIFC1 3833
Co-fractionation Homo sapiens
15 RPA1 6117
Affinity Capture-MS Homo sapiens
16 ELP3 55140
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 RPL10 6134
Affinity Capture-MS Homo sapiens
18 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
19 FBLN1 2192
Affinity Capture-MS Homo sapiens
20 TERF2IP 54386
Two-hybrid Homo sapiens
21 OTUB1 55611
Affinity Capture-MS Homo sapiens
22 GHITM 27069
Affinity Capture-MS Homo sapiens
23 ELP2 55250
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 APP 351
Reconstituted Complex Homo sapiens
25 EIF2A 83939
Co-fractionation Homo sapiens
26 ESR1  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 GSTM3 2947
Affinity Capture-MS Homo sapiens
28 Srp72  
Affinity Capture-MS Mus musculus
29 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
30 USP7 7874
Affinity Capture-MS Homo sapiens
31 GPR182  
Two-hybrid Homo sapiens
32 Rrbp1  
Affinity Capture-MS Mus musculus
33 NPM1 4869
Affinity Capture-MS Homo sapiens
34 MDC1  
Affinity Capture-MS Homo sapiens
35 Rpl35 66489
Affinity Capture-MS Mus musculus
36 RANBP1 5902
Affinity Capture-MS Homo sapiens
37 HECW2  
Affinity Capture-MS Homo sapiens
38 BRD3 8019
Affinity Capture-MS Homo sapiens
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