Gene description for MPG
Gene name N-methylpurine-DNA glycosylase
Gene symbol MPG
Other names/aliases AAG
ADPG
APNG
CRA36.1
MDG
Mid1
PIG11
PIG16
anpg
Species Homo sapiens
 Database cross references - MPG
ExoCarta ExoCarta_4350
Vesiclepedia VP_4350
Entrez Gene 4350
HGNC 7211
MIM 156565
UniProt P29372  
 MPG identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for MPG
Molecular Function
    DNA-7-methylguanine glycosylase activity GO:0043916 IEA
    damaged DNA binding GO:0003684 TAS
    DNA-3-methylguanine glycosylase activity GO:0052822 IEA
    DNA-7-methyladenine glycosylase activity GO:0052821 IEA
    DNA-3-methyladenine glycosylase activity GO:0008725 IEA
    protein binding GO:0005515 IPI
    alkylbase DNA N-glycosylase activity GO:0003905 IBA
Biological Process
    depurination GO:0045007 TAS
    DNA repair GO:0006281 TAS
    DNA dealkylation involved in DNA repair GO:0006307 TAS
    base-excision repair GO:0006284 TAS
    base-excision repair, AP site formation GO:0006285 TAS
Subcellular Localization
    nucleoplasm GO:0005654 TAS
    mitochondrial nucleoid GO:0042645 IEA
 Experiment description of studies that identified MPG in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for MPG
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GSTM3 2947
Affinity Capture-MS Homo sapiens
2 RAD23B 5887
Affinity Capture-MS Homo sapiens
3 GOT2 2806
Affinity Capture-MS Homo sapiens
4 RANBP1 5902
Affinity Capture-MS Homo sapiens
5 FBLN1 2192
Affinity Capture-MS Homo sapiens
6 RAD23A 5886
Affinity Capture-MS Homo sapiens
7 LRRC59 55379
Affinity Capture-MS Homo sapiens
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