Gene description for BCL2L12
Gene name BCL2-like 12 (proline rich)
Gene symbol BCL2L12
Other names/aliases -
Species Homo sapiens
 Database cross references - BCL2L12
ExoCarta ExoCarta_83596
Entrez Gene 83596
HGNC 13787
MIM 610837
UniProt Q9HB09  
 BCL2L12 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for BCL2L12
Molecular Function
    p53 binding GO:0002039 IEA
    protein binding GO:0005515 IPI
Biological Process
    negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator GO:1902166 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
    negative regulation of cellular senescence GO:2000773 IEA
    inhibition of cysteine-type endopeptidase activity involved in apoptotic process GO:1990001 IDA
Subcellular Localization
    nucleus GO:0005634 IDA
    membrane GO:0016020 IDA
 Experiment description of studies that identified BCL2L12 in exosomes
1
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for BCL2L12
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BCL2L1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which BCL2L12 is involved
No pathways found





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