Gene description for IQSEC1
Gene name IQ motif and Sec7 domain 1
Gene symbol IQSEC1
Other names/aliases ARF-GEP100
ARFGEP100
BRAG2
GEP100
Species Homo sapiens
 Database cross references - IQSEC1
ExoCarta ExoCarta_9922
Entrez Gene 9922
HGNC 29112
MIM 610166
UniProt Q6DN90  
 IQSEC1 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for IQSEC1
Molecular Function
    ARF guanyl-nucleotide exchange factor activity GO:0005086 IBA
    lipid binding GO:0008289 IEA
Biological Process
    positive regulation of GTPase activity GO:0043547 IEA
    actin cytoskeleton organization GO:0030036 IBA
    vesicle-mediated transport GO:0016192 IBA
Subcellular Localization
    nucleus GO:0005634 IEA
    trans-Golgi network GO:0005802 IBA
    membrane GO:0016020 IDA
 Experiment description of studies that identified IQSEC1 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for IQSEC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which IQSEC1 is involved
No pathways found





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