Gene description for F7
Gene name coagulation factor VII (serum prothrombin conversion accelerator)
Gene symbol F7
Other names/aliases SPCA
Species Homo sapiens
 Database cross references - F7
ExoCarta ExoCarta_2155
Entrez Gene 2155
HGNC 3544
MIM 613878
UniProt P08709  
 F7 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
 Gene ontology annotations for F7
Molecular Function
    protein binding GO:0005515 IPI
    calcium ion binding GO:0005509 IEA
    glycoprotein binding GO:0001948 IPI
    receptor binding GO:0005102 IEA
    serine-type endopeptidase activity GO:0004252 IEA
    serine-type peptidase activity GO:0008236 TAS
Biological Process
    organ regeneration GO:0031100 IEA
    cellular protein metabolic process GO:0044267 TAS
    positive regulation of blood coagulation GO:0030194 IEA
    positive regulation of platelet-derived growth factor receptor signaling pathway GO:0010641 IDA
    peptidyl-glutamic acid carboxylation GO:0017187 TAS
    proteolysis GO:0006508 TAS
    positive regulation of cell migration GO:0030335 TAS
    positive regulation of positive chemotaxis GO:0050927 IDA
    response to vitamin K GO:0032571 IEA
    blood coagulation GO:0007596 TAS
    blood coagulation, extrinsic pathway GO:0007598 TAS
    circadian rhythm GO:0007623 TAS
    positive regulation of leukocyte chemotaxis GO:0002690 IDA
    response to growth hormone GO:0060416 IEA
    response to estrogen GO:0043627 IEA
    positive regulation of protein kinase B signaling GO:0051897 IDA
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    extracellular region GO:0005576 TAS
    vesicle GO:0031982 IEA
    Golgi lumen GO:0005796 TAS
    extracellular space GO:0005615 IEA
    endoplasmic reticulum lumen GO:0005788 TAS
    plasma membrane GO:0005886 TAS
 Experiment description of studies that identified F7 in exosomes
Experiment ID 21
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
 Protein-protein interactions for F7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 F9 2158
Invitro Homo sapiens
2 F3 2152
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
3 F7 2155
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
4 F10 2159
Biochemical Activity Homo sapiens
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