Gene description for GFRA1
Gene name GDNF family receptor alpha 1
Gene symbol GFRA1
Other names/aliases GDNFR
GDNFRA
GFR-ALPHA-1
RET1L
RETL1
TRNR1
Species Homo sapiens
 Database cross references - GFRA1
ExoCarta ExoCarta_2674
Vesiclepedia VP_2674
Entrez Gene 2674
HGNC 4243
MIM 601496
UniProt P56159  
 GFRA1 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GFRA1
Molecular Function
    neurotrophin receptor activity GO:0005030 IEA
    signaling receptor binding GO:0005102 TAS
    integrin binding GO:0005178 IEA
    protein binding GO:0005515 IPI
    glial cell-derived neurotrophic factor receptor activity GO:0016167 IDA
    signaling receptor activity GO:0038023 IBA
Biological Process
    kidney development GO:0001822 IEA
    cell surface receptor signaling pathway GO:0007166 NAS
    nervous system development GO:0007399 IBA
    male gonad development GO:0008584 IEA
    cell migration GO:0016477 IEA
    neuron projection development GO:0031175 IEA
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 IDA
    neurotrophin signaling pathway GO:0038179 IEA
    positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 IEA
Subcellular Localization
    multivesicular body GO:0005771 IEA
    Golgi apparatus GO:0005794 IEA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    external side of plasma membrane GO:0009897 IBA
    extrinsic component of membrane GO:0019898 TAS
    axon GO:0030424 IEA
    neuronal cell body GO:0043025 IEA
    receptor complex GO:0043235 IBA
    extracellular exosome GO:0070062 HDA
    plasma membrane protein complex GO:0098797 IEA
 Experiment description of studies that identified GFRA1 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GFRA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BAG3 9531
Affinity Capture-Luminescence Homo sapiens
2 KRT18 3875
Co-fractionation Homo sapiens
3 HNRNPDL 9987
Co-fractionation Homo sapiens
4 PFN2 5217
Co-fractionation Homo sapiens
5 KIF2A 3796
Co-fractionation Homo sapiens
6 SOCS3 9021
Two-hybrid Homo sapiens
7 AHCY 191
Co-fractionation Homo sapiens
8 AIFM1 9131
Co-fractionation Homo sapiens
9 TTC4  
Co-fractionation Homo sapiens
10 PRMT3 10196
Co-fractionation Homo sapiens
11 RET 5979
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
12 NRTN  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
13 TACC2 10579
Co-fractionation Homo sapiens
14 CAPZB 832
Co-fractionation Homo sapiens
15 RPS6KB1 6198
Co-fractionation Homo sapiens
16 RDX 5962
Co-fractionation Homo sapiens
17 DDX5 1655
Co-fractionation Homo sapiens
18 KIF5B 3799
Co-fractionation Homo sapiens
19 PSMB5 5693
Co-fractionation Homo sapiens
20 GDNF  
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
21 UBA6 55236
Co-fractionation Homo sapiens
22 GSPT1 2935
Co-fractionation Homo sapiens
23 MGEA5 10724
Co-fractionation Homo sapiens
24 NAA10 8260
Co-fractionation Homo sapiens
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