Gene description for GFRA1
Gene name GDNF family receptor alpha 1
Gene symbol GFRA1
Other names/aliases GDNFR
GDNFRA
GFR-ALPHA-1
RET1L
RETL1
TRNR1
Species Homo sapiens
 Database cross references - GFRA1
ExoCarta ExoCarta_2674
Entrez Gene 2674
HGNC 4243
MIM 601496
UniProt P56159  
 GFRA1 identified in exosomes derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GFRA1
Molecular Function
    receptor binding GO:0005102 TAS
    glial cell-derived neurotrophic factor receptor activity GO:0016167 TAS
Biological Process
    glial cell-derived neurotrophic factor receptor signaling pathway GO:0035860 TAS
    cell surface receptor signaling pathway GO:0007166 NAS
    axon guidance GO:0007411 TAS
Subcellular Localization
    anchored component of membrane GO:0031225 IEA
    plasma membrane GO:0005886 IEA
    extrinsic component of membrane GO:0019898 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified GFRA1 in exosomes
1
Experiment ID 63
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✔
AQP2
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GFRA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GDNF  
Invivo Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
Invitro Homo sapiens
Reconstituted Complex Homo sapiens
2 RET 5979
Invivo Homo sapiens
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
3 NRTN  
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which GFRA1 is involved
PathwayEvidenceSource
NCAM1 interactions TAS Reactome





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