Gene description for TACC2
Gene name transforming, acidic coiled-coil containing protein 2
Gene symbol TACC2
Other names/aliases AZU-1
ECTACC
Species Homo sapiens
 Database cross references - TACC2
ExoCarta ExoCarta_10579
Vesiclepedia VP_10579
Entrez Gene 10579
HGNC 11523
MIM 605302
UniProt O95359  
 TACC2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for TACC2
Molecular Function
    nuclear receptor binding GO:0016922 IDA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    mitotic spindle organization GO:0007052 IEA
    nuclear migration GO:0007097 IBA
    cerebral cortex development GO:0021987 IBA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified TACC2 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
2
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TACC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMG20B  
Two-hybrid Homo sapiens
2 LARP1 23367
Co-fractionation Homo sapiens
3 Haus1  
Affinity Capture-MS Mus musculus
4 YEATS4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
5 HSD17B11 51170
Proximity Label-MS Homo sapiens
6 SMARCB1 6598
Affinity Capture-Western Homo sapiens
7 GEMIN5 25929
Co-fractionation Homo sapiens
8 KAT2A  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
9 KIF21A 55605
Affinity Capture-MS Homo sapiens
10 Haus4  
Affinity Capture-MS Mus musculus
11 YWHAZ 7534
Affinity Capture-MS Homo sapiens
12 NUP155 9631
Co-fractionation Homo sapiens
13 YWHAE 7531
Affinity Capture-MS Homo sapiens
14 KAT2B  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
15 HIST1H1E 3008
Co-fractionation Homo sapiens
16 AURKC  
Two-hybrid Homo sapiens
17 FOXA1  
Affinity Capture-MS Homo sapiens
18 MAP4 4134
Affinity Capture-MS Homo sapiens
19 Ckap5 75786
Affinity Capture-MS Mus musculus
20 ATG9A 79065
Proximity Label-MS Homo sapiens
21 TUBB4B 10383
Affinity Capture-MS Homo sapiens
22 FKBP8 23770
Proximity Label-MS Homo sapiens
23 KIF5B 3799
Co-fractionation Homo sapiens
24 CREBBP  
Affinity Capture-Western Homo sapiens
25 CAPZB 832
Co-fractionation Homo sapiens
26 PTPN1 5770
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
27 DDX58 23586
Affinity Capture-RNA Homo sapiens
28 GFRA1 2674
Co-fractionation Homo sapiens
29 CLVS2 134829
Two-hybrid Homo sapiens
30 MAPRE1 22919
Proximity Label-MS Homo sapiens
31 RCC2 55920
Co-fractionation Homo sapiens
32 PPP1CC 5501
Two-hybrid Homo sapiens
33 MAPRE3  
Proximity Label-MS Homo sapiens
34 SLAIN2  
Affinity Capture-MS Homo sapiens
35 TUBA1B 10376
Affinity Capture-MS Homo sapiens
36 PRC1 9055
Co-fractionation Homo sapiens
37 CKAP5 9793
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 SOSTDC1  
Affinity Capture-MS Homo sapiens
39 KXD1 79036
Affinity Capture-MS Homo sapiens
40 CLK2 1196
Two-hybrid Homo sapiens
41 PEX14 5195
Proximity Label-MS Homo sapiens
42 EP300 2033
Affinity Capture-Western Homo sapiens
43 TACC1 6867
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 SMS 6611
Co-fractionation Homo sapiens
45 HECTD1 25831
Affinity Capture-MS Homo sapiens
46 CTR9 9646
Affinity Capture-MS Homo sapiens
47 C9orf142  
Affinity Capture-MS Homo sapiens
48 HSPA9 3313
Co-fractionation Homo sapiens
49 RHOT2 89941
Proximity Label-MS Homo sapiens
50 SEC61B 10952
Proximity Label-MS Homo sapiens
51 C17orf59 54785
Two-hybrid Homo sapiens
52 Slain1  
Affinity Capture-MS Mus musculus
53 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which TACC2 is involved
No pathways found





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