Gene description for TACC2
Gene name transforming, acidic coiled-coil containing protein 2
Gene symbol TACC2
Other names/aliases AZU-1
Species Homo sapiens
 Database cross references - TACC2
ExoCarta ExoCarta_10579
Entrez Gene 10579
HGNC 11523
MIM 605302
UniProt O95359  
 TACC2 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
Neuroblastoma cells 25944692    
 Gene ontology annotations for TACC2
Molecular Function
    nuclear hormone receptor binding GO:0035257 IDA
    protein domain specific binding GO:0019904 IEA
Biological Process
    microtubule cytoskeleton organization GO:0000226 IBA
    interkinetic nuclear migration GO:0022027 IEA
    astral microtubule organization GO:0030953 IEA
    regulation of microtubule-based process GO:0032886 IEA
    neurogenesis GO:0022008 IEA
    cell proliferation GO:0008283 IBA
    cerebral cortex development GO:0021987 IBA
Subcellular Localization
    nucleus GO:0005634 IDA
    microtubule organizing center GO:0005815 IEA
    microtubule cytoskeleton GO:0015630 IBA
    nucleolus GO:0005730 IDA
    cytoplasm GO:0005737 IBA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified TACC2 in exosomes
Experiment ID 235
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
Experiment ID 224
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TACC2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HMG20B  
Two-hybrid Homo sapiens
2 SMARCB1 6598
Affinity Capture-Western Homo sapiens
3 YEATS4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which TACC2 is involved
No pathways found

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