Gene description for SMARCB1
Gene name SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
Gene symbol SMARCB1
Other names/aliases BAF47
INI1
MRD15
PPP1R144
RDT
RTPS1
SNF5
SNF5L1
SWNTS1
Sfh1p
Snr1
hSNFS
Species Homo sapiens
 Database cross references - SMARCB1
ExoCarta ExoCarta_6598
Entrez Gene 6598
HGNC 11103
MIM 601607
UniProt Q12824  
 SMARCB1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Thymus 23844026    
 Gene ontology annotations for SMARCB1
Molecular Function
    Tat protein binding GO:0030957 IPI
    RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 IDA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IDA
    protein binding GO:0005515 IPI
    transcription coactivator activity GO:0003713 NAS
    p53 binding GO:0002039 IPI
    nucleosomal DNA binding GO:0031492 IDA
Biological Process
    positive regulation by host of viral transcription GO:0043923 IMP
    DNA integration GO:0015074 TAS
    ATP-dependent chromatin remodeling GO:0043044 IDA
    nucleosome disassembly GO:0006337 IDA
    single stranded viral RNA replication via double stranded DNA intermediate GO:0039692 IDA
    mitotic cell cycle phase transition GO:0044772 IBA
    chromatin organization GO:0006325 TAS
    chromatin remodeling GO:0006338 IDA
    transcription, DNA-templated GO:0006351 IEA
    negative regulation of cell proliferation GO:0008285 IBA
    nervous system development GO:0007399 IEA
    positive regulation of sequence-specific DNA binding transcription factor activity GO:0051091 IDA
    regulation of transcription from RNA polymerase II promoter GO:0006357 NAS
    DNA repair GO:0006281 IBA
    cell differentiation GO:0030154 IBA
    blastocyst hatching GO:0001835 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA
Subcellular Localization
    XY body GO:0001741 IEA
    SWI/SNF complex GO:0016514 IDA
    nucleus GO:0005634 IDA
    nucleolus GO:0005730 IDA
    nucleoplasm GO:0005654 TAS
    protein complex GO:0043234 IDA
    npBAF complex GO:0071564 ISS
    nBAF complex GO:0071565 ISS
    nuclear chromatin GO:0000790 IDA
 Experiment description of studies that identified SMARCB1 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SMARCB1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 GATA1  
Reconstituted Complex Homo sapiens
2 YEATS4  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
3 SS18  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
4 PPP1CB 5500
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
5 MLLT10  
Affinity Capture-Western Homo sapiens
6 SMARCB1 6598
Co-purification Homo sapiens
Co-purification Homo sapiens
7 KLF1  
Reconstituted Complex Homo sapiens
8 ACTL6A 86
Co-purification Homo sapiens
9 SIN3A  
Co-purification Homo sapiens
10 BAZ1B 9031
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
11 XPO1 7514
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
12 ARID1B 57492
Affinity Capture-MS Homo sapiens
13 MLL  
Affinity Capture-Western Homo sapiens
14 SMARCC1 6599
Co-purification Homo sapiens
Co-purification Homo sapiens
15 PPP1CA 5499
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
16 BRCA1 672
Co-purification Homo sapiens
Co-purification Homo sapiens
17 Myc  
Reconstituted Complex Mus musculus
18 SMARCE1 6605
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
19 CCNE1  
Affinity Capture-Western Homo sapiens
20 PCAF  
Affinity Capture-Western Homo sapiens
21 CREBBP  
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
22 POLR2A 5430
Co-fractionation Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
23 RBBP4 5928
Co-purification Homo sapiens
24 TACC2 10579
Affinity Capture-Western Homo sapiens
25 HDAC1 3065
Co-purification Homo sapiens
26 PPP1CC 5501
Phenotypic Enhancement Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 SMARCA2  
Co-purification Homo sapiens
Co-purification Homo sapiens
Co-purification Homo sapiens
28 SMARCA4 6597
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Co-purification Homo sapiens
29 NCOR1  
Co-purification Homo sapiens
30 CDK8  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
31 ING1  
Affinity Capture-MS Homo sapiens
32 HSF1  
Co-fractionation Homo sapiens
33 HDAC2 3066
Co-purification Homo sapiens
34 TP53  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
35 RELB  
Affinity Capture-MS Homo sapiens
36 UBQLN4 56893
Two-hybrid Homo sapiens
37 SURB7  
Affinity Capture-Western Homo sapiens
38 MYC  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
39 ARID1A 8289
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
40 SMARCC2 6601
Co-purification Homo sapiens
41 PPP1R15A  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
42 RAN 5901
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which SMARCB1 is involved
PathwayEvidenceSource
RMTs methylate histone arginines TAS Reactome





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