Gene description for KMT2C
Gene name lysine (K)-specific methyltransferase 2C
Gene symbol KMT2C
Other names/aliases HALR
MLL3
Species Homo sapiens
 Database cross references - KMT2C
ExoCarta ExoCarta_58508
Vesiclepedia VP_58508
Entrez Gene 58508
HGNC 13726
MIM 606833
UniProt Q8NEZ4  
 KMT2C identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for KMT2C
Molecular Function
    DNA binding GO:0003677 IEA
    transcription coactivator activity GO:0003713 IBA
    RNA binding GO:0003723 HDA
    protein binding GO:0005515 IPI
    acyltransferase activity GO:0016746 IEA
    histone methyltransferase activity GO:0042054 IDA
    histone H3K4 methyltransferase activity GO:0042800 IBA
    histone H3K4 methyltransferase activity GO:0042800 IDA
    metal ion binding GO:0046872 IEA
    histone H3K4 monomethyltransferase activity GO:0140945 IEA
    histone H3K4 trimethyltransferase activity GO:0140999 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    methylation GO:0032259 IEA
    positive regulation of transcription by RNA polymerase II GO:0045944 IBA
    response to electrical stimulus GO:0051602 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    cytosol GO:0005829 IDA
    histone methyltransferase complex GO:0035097 IDA
    MLL3/4 complex GO:0044666 IBA
    MLL3/4 complex GO:0044666 IDA
    MLL3/4 complex GO:0044666 IPI
 Experiment description of studies that identified KMT2C in exosomes
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for KMT2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NCOA6  
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
2 IRF4  
Proximity Label-MS Homo sapiens
3 PAXIP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
4 NFIB  
Proximity Label-MS Homo sapiens
5 FEV  
Proximity Label-MS Homo sapiens
6 LHX2  
Proximity Label-MS Homo sapiens
7 GATA2  
Proximity Label-MS Homo sapiens
8 EN1  
Proximity Label-MS Homo sapiens
9 PAX2  
Proximity Label-MS Homo sapiens
10 HIST1H2BB 3018
Reconstituted Complex Homo sapiens
11 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
12 KDM6A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 KANSL3  
Affinity Capture-MS Homo sapiens
14 SOX9  
Proximity Label-MS Homo sapiens
15 SOX2  
Proximity Label-MS Homo sapiens
16 MYOD1  
Proximity Label-MS Homo sapiens
17 NUP35 129401
Proximity Label-MS Homo sapiens
18 KMT2D 8085
Affinity Capture-MS Homo sapiens
19 MAPK14 1432
Two-hybrid Homo sapiens
20 GCM1  
Proximity Label-MS Homo sapiens
21 BOD1L1 259282
Affinity Capture-MS Homo sapiens
22 HIST1H3A 8350
Reconstituted Complex Homo sapiens
Protein-peptide Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
23 TEAD1  
Proximity Label-MS Homo sapiens
24 DYNLL1 8655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 KLF4  
Proximity Label-MS Homo sapiens
26 ASH2L 9070
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
27 LHX4  
Proximity Label-MS Homo sapiens
28 SETD1A 9739
Affinity Capture-MS Homo sapiens
29 WDR5 11091
Co-crystal Structure Homo sapiens
Protein-peptide Homo sapiens
Affinity Capture-MS Homo sapiens
Protein-peptide Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
30 SMARCB1 6598
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
31 MTNR1B  
Two-hybrid Homo sapiens
32 CXXC1  
Affinity Capture-MS Homo sapiens
33 HNF1A  
Proximity Label-MS Homo sapiens
34 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-crystal Structure Homo sapiens
35 TLX3  
Proximity Label-MS Homo sapiens
36 HCFC2  
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 TBR1  
Proximity Label-MS Homo sapiens
39 NFIX 4784
Proximity Label-MS Homo sapiens
40 ASCL2  
Affinity Capture-Western Homo sapiens
41 LHX1  
Proximity Label-MS Homo sapiens
42 KDM4B  
Affinity Capture-Western Homo sapiens
43 LHX3  
Proximity Label-MS Homo sapiens
44 PAX8  
Proximity Label-MS Homo sapiens
45 DYNLL2 140735
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 T  
Proximity Label-MS Homo sapiens
47 CEBPA  
Proximity Label-MS Homo sapiens
48 SOX17  
Proximity Label-MS Homo sapiens
49 HIST1H2AB 8335
Reconstituted Complex Homo sapiens
50 SOX7  
Proximity Label-MS Homo sapiens
51 WDR82 80335
Affinity Capture-MS Homo sapiens
52 TLX2  
Proximity Label-MS Homo sapiens
53 PAX6  
Proximity Label-MS Homo sapiens
54 PAGR1  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 KMT2A  
Affinity Capture-MS Homo sapiens
56 CDC73  
Affinity Capture-MS Homo sapiens
57 HIST2H3C 126961
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
58 PPARG 5468
Proximity Label-MS Homo sapiens
59 HCFC1 3054
Affinity Capture-MS Homo sapiens
60 FOXI1  
Proximity Label-MS Homo sapiens
61 CUL3 8452
Affinity Capture-MS Homo sapiens
62 FOXL1  
Proximity Label-MS Homo sapiens
63 HIST3H3 8290
Biochemical Activity Homo sapiens
64 Paxip1  
Affinity Capture-MS Mus musculus
65 ERP44 23071
Affinity Capture-MS Homo sapiens
66 JUN 3725
Two-hybrid Homo sapiens
67 HNF4A  
Proximity Label-MS Homo sapiens
68 FOS 2353
Proximity Label-MS Homo sapiens
69 RPA3 6119
Proximity Label-MS Homo sapiens
70 KLF15  
Proximity Label-MS Homo sapiens
71 ATN1  
Affinity Capture-MS Homo sapiens
72 RBBP5 5929
Co-purification Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
73 PIGR 5284
Affinity Capture-MS Homo sapiens
74 TLX1  
Proximity Label-MS Homo sapiens
75 FASN 2194
Negative Genetic Homo sapiens
76 PHF20  
Affinity Capture-MS Homo sapiens
77 UTY  
Affinity Capture-MS Homo sapiens
78 ELF5  
Proximity Label-MS Homo sapiens
79 H3F3A 3020
Affinity Capture-MS Homo sapiens
80 KMT2B  
Affinity Capture-MS Homo sapiens
81 MEN1 4221
Affinity Capture-MS Homo sapiens
82 DPY30 84661
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
83 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
84 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
85 PAX9  
Proximity Label-MS Homo sapiens
86 BUB3 9184
Affinity Capture-MS Homo sapiens
87 SETD1B 23067
Affinity Capture-MS Homo sapiens
88 KLF5  
Proximity Label-MS Homo sapiens
89 PAX7  
Proximity Label-MS Homo sapiens
90 TSC22D1 8848
Two-hybrid Homo sapiens
91 ERG  
Proximity Label-MS Homo sapiens
92 HNF1B  
Proximity Label-MS Homo sapiens
93 PHF20L1  
Affinity Capture-MS Homo sapiens
94 SP7  
Proximity Label-MS Homo sapiens
95 AK1 203
Affinity Capture-MS Homo sapiens
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