Gene description for KMT2C
Gene name lysine (K)-specific methyltransferase 2C
Gene symbol KMT2C
Other names/aliases HALR
Species Homo sapiens
 Database cross references - KMT2C
ExoCarta ExoCarta_58508
Entrez Gene 58508
HGNC 13726
MIM 606833
UniProt Q8NEZ4  
 KMT2C identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for KMT2C
Molecular Function
    DNA binding GO:0003677 IEA
    histone methyltransferase activity (H3-K4 specific) GO:0042800 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    intracellular signal transduction GO:0035556 IEA
    transcription, DNA-templated GO:0006351 IEA
    chromatin organization GO:0006325 TAS
    histone H3-K4 methylation GO:0051568 IDA
    regulation of transcription, DNA-templated GO:0006355 IEA
Subcellular Localization
    nucleus GO:0005634 IDA
    histone methyltransferase complex GO:0035097 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified KMT2C in exosomes
Experiment ID 274
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for KMT2C
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ASH2L  
Reconstituted Complex Homo sapiens
2 NCOA6  
Affinity Capture-MS Homo sapiens
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
3 ASCL2  
Affinity Capture-Western Homo sapiens
4 AK1 203
Affinity Capture-MS Homo sapiens
5 HIST2H3C 126961
Reconstituted Complex Homo sapiens
6 RBBP5  
Co-purification Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which KMT2C is involved
PKMTs methylate histone lysines TAS Reactome

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