Gene description for CLVS2
Gene name clavesin 2
Gene symbol CLVS2
Other names/aliases C6orf212
C6orf213
RLBP1L2
bA160A10.4
Species Homo sapiens
 Database cross references - CLVS2
ExoCarta ExoCarta_134829
Entrez Gene 134829
HGNC 23046
UniProt Q5SYC1  
 CLVS2 identified in exosomes derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CLVS2
Molecular Function
    transporter activity GO:0005215 IEA
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
Biological Process
    lysosome organization GO:0007040 ISS
    post-Golgi vesicle-mediated transport GO:0006892 TAS
    membrane organization GO:0061024 TAS
Subcellular Localization
    clathrin-coated endocytic vesicle membrane GO:0030669 TAS
    trans-Golgi network membrane GO:0032588 TAS
    early endosome membrane GO:0031901 IEA
    trans-Golgi network GO:0005802 ISS
    endosome GO:0005768 IDA
    clathrin-coated vesicle GO:0030136 ISS
 Experiment description of studies that identified CLVS2 in exosomes
1
Experiment ID 193
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63|CD9
EV Membrane markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
ISEV standards
✘ EV Biophysical techniques
✘ EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLVS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which CLVS2 is involved
PathwayEvidenceSource
Lysosome Vesicle Biogenesis TAS Reactome





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