Gene description for CLVS2
Gene name clavesin 2
Gene symbol CLVS2
Other names/aliases C6orf212
C6orf213
RLBP1L2
bA160A10.4
Species Homo sapiens
 Database cross references - CLVS2
ExoCarta ExoCarta_134829
Vesiclepedia VP_134829
Entrez Gene 134829
HGNC 23046
UniProt Q5SYC1  
 CLVS2 identified in sEVs derived from the following tissue/cell type
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for CLVS2
Molecular Function
    protein binding GO:0005515 IPI
    phosphatidylinositol-3,5-bisphosphate binding GO:0080025 IDA
    phosphatidylinositol bisphosphate binding GO:1902936 IBA
Biological Process
    lysosome organization GO:0007040 IBA
    lysosome organization GO:0007040 ISS
Subcellular Localization
    endosome GO:0005768 IBA
    endosome GO:0005768 IDA
    trans-Golgi network GO:0005802 IBA
    trans-Golgi network GO:0005802 ISS
    clathrin-coated vesicle GO:0030136 IBA
    clathrin-coated vesicle GO:0030136 ISS
    early endosome membrane GO:0031901 IEA
    trans-Golgi network membrane GO:0032588 TAS
 Experiment description of studies that identified CLVS2 in sEVs
1
Experiment ID 193
MISEV standards
✔
EM
Biophysical techniques
✔
CD63|CD9
Enriched markers
✔
PHB
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 194
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 195
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors "Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC."
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CLVS2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACC2 10579
Two-hybrid Homo sapiens
2 MEOX2  
Two-hybrid Homo sapiens
3 LDLR 3949
Positive Genetic Homo sapiens
4 GSTZ1 2954
Two-hybrid Homo sapiens
5 APEX1 328
Co-fractionation Homo sapiens
6 DDX41 51428
Co-fractionation Homo sapiens
7 FBXW2  
Two-hybrid Homo sapiens
8 GSTM3 2947
Two-hybrid Homo sapiens
9 PAFAH1B2 5049
Two-hybrid Homo sapiens
10 S100A7 6278
Two-hybrid Homo sapiens
11 C11orf30  
Two-hybrid Homo sapiens
12 PGAM2 5224
Two-hybrid Homo sapiens
13 FLAD1 80308
Two-hybrid Homo sapiens
14 KAZN  
Two-hybrid Homo sapiens
15 S100A7A 338324
Two-hybrid Homo sapiens
16 FAM109B  
Two-hybrid Homo sapiens
17 GYS1 2997
Two-hybrid Homo sapiens
18 PCYT2 5833
Two-hybrid Homo sapiens
19 NHP2L1 4809
Co-fractionation Homo sapiens
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