Gene description for CLEC3B
Gene name C-type lectin domain family 3, member B
Gene symbol CLEC3B
Other names/aliases TN
TNA
Species Homo sapiens
 Database cross references - CLEC3B
ExoCarta ExoCarta_7123
Vesiclepedia VP_7123
Entrez Gene 7123
HGNC 11891
MIM 187520
UniProt P05452  
 CLEC3B identified in sEVs derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for CLEC3B
Molecular Function
    calcium ion binding GO:0005509 IDA
    heparin binding GO:0008201 IDA
    carbohydrate binding GO:0030246 IEA
    kringle domain binding GO:0036143 IPI
Biological Process
    ossification GO:0001503 IBA
    ossification GO:0001503 IEP
    positive regulation of plasminogen activation GO:0010756 ISS
    bone mineralization GO:0030282 IBA
    bone mineralization GO:0030282 IDA
Subcellular Localization
    granular component GO:0001652 IDA
    extracellular region GO:0005576 HDA
    extracellular region GO:0005576 NAS
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 HDA
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IDA
    platelet dense granule lumen GO:0031089 TAS
    collagen-containing extracellular matrix GO:0062023 HDA
    collagen-containing extracellular matrix GO:0062023 ISS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CLEC3B in sEVs
1
Experiment ID 275
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CLEC3B
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 APP 351
Reconstituted Complex Homo sapiens
2 GADD45A  
Two-hybrid Homo sapiens
3 HGF 3082
Reconstituted Complex Homo sapiens
4 KRT18 3875
Affinity Capture-MS Homo sapiens
5 RIT1 6016
Negative Genetic Homo sapiens
6 ANXA7 310
Two-hybrid Homo sapiens
7 GSK3B 2932
Two-hybrid Homo sapiens
8 RPS6KB1 6198
Two-hybrid Homo sapiens
9 OTUD4  
Affinity Capture-MS Homo sapiens
10 PLAT 5327
Reconstituted Complex Homo sapiens
11 THRAP3 9967
Affinity Capture-MS Homo sapiens
12 TK1 7083
Two-hybrid Homo sapiens
13 CDKN1A  
Two-hybrid Homo sapiens
14 SH3GL2  
Two-hybrid Homo sapiens
15 RPS6KA6 27330
Two-hybrid Homo sapiens
16 OSTF1 26578
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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