Gene description for PHYHIP
Gene name phytanoyl-CoA 2-hydroxylase interacting protein
Gene symbol PHYHIP
Other names/aliases DYRK1AP3
Species Homo sapiens
 Database cross references - PHYHIP
ExoCarta ExoCarta_9796
Entrez Gene 9796
HGNC 16865
MIM 608511
UniProt Q92561  
 PHYHIP identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for PHYHIP
Biological Process
    positive regulation of defense response to virus by host GO:0002230 IMP
    activation of mitophagy in response to mitochondrial depolarization GO:0098779 IMP
 Experiment description of studies that identified PHYHIP in exosomes
Experiment ID 237
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for PHYHIP
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EEF1A1 1915
Two-hybrid Homo sapiens
2 MGC9084  
Two-hybrid Homo sapiens
3 PRMT5 10419
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
5 ZZEF1 23140
Two-hybrid Homo sapiens
6 MED8  
Two-hybrid Homo sapiens
7 NDRG1 10397
Two-hybrid Homo sapiens
8 PNPLA2  
Two-hybrid Homo sapiens
9 C14orf1 11161
Two-hybrid Homo sapiens
10 TTR 7276
Two-hybrid Homo sapiens
11 NDUFV3  
Two-hybrid Homo sapiens
12 S100A13 6284
Two-hybrid Homo sapiens
13 C14orf150  
Two-hybrid Homo sapiens
14 Supt5h  
Two-hybrid Mus musculus
15 HDAC11  
Two-hybrid Homo sapiens
16 COPS6 10980
Two-hybrid Homo sapiens
17 PPIE 10450
Two-hybrid Homo sapiens
18 MGC21688  
Two-hybrid Homo sapiens
19 SMARCC2 6601
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PHYHIP is involved
No pathways found

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