Gene description for NUP88
Gene name nucleoporin 88kDa
Gene symbol NUP88
Other names/aliases -
Species Homo sapiens
 Database cross references - NUP88
ExoCarta ExoCarta_4927
Entrez Gene 4927
HGNC 8067
MIM 602552
UniProt Q99567  
 NUP88 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for NUP88
Molecular Function
    transporter activity GO:0005215 TAS
Biological Process
    cellular protein metabolic process GO:0044267 TAS
    carbohydrate metabolic process GO:0005975 TAS
    small molecule metabolic process GO:0044281 TAS
    hexose transport GO:0008645 TAS
    viral life cycle GO:0019058 TAS
    mRNA transport GO:0051028 IEA
    glucose transport GO:0015758 TAS
    protein sumoylation GO:0016925 TAS
    transmembrane transport GO:0055085 TAS
    viral transcription GO:0019083 TAS
    mitotic nuclear envelope disassembly GO:0007077 TAS
    regulation of cellular response to heat GO:1900034 TAS
    cytokine-mediated signaling pathway GO:0019221 TAS
    protein transport GO:0015031 IEA
    regulation of glucose transport GO:0010827 TAS
    viral process GO:0016032 TAS
    cellular response to heat GO:0034605 TAS
    mitotic cell cycle GO:0000278 TAS
    gene expression GO:0010467 TAS
    post-translational protein modification GO:0043687 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    nuclear pore GO:0005643 IDA
    nucleoplasm GO:0005654 IDA
 Experiment description of studies that identified NUP88 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NUP88
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 NUP98 4928
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
View the network image/svg+xml



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