Gene description for HVCN1
Gene name hydrogen voltage gated channel 1
Gene symbol HVCN1
Other names/aliases HV1
VSOP
Species Homo sapiens
 Database cross references - HVCN1
ExoCarta ExoCarta_84329
Vesiclepedia VP_84329
Entrez Gene 84329
HGNC 28240
MIM 611227
UniProt Q96D96  
 HVCN1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for HVCN1
Molecular Function
    protein binding GO:0005515 IPI
    voltage-gated monoatomic cation channel activity GO:0022843 EXP
    voltage-gated proton channel activity GO:0030171 IBA
    voltage-gated proton channel activity GO:0030171 IDA
    voltage-gated proton channel activity GO:0030171 IMP
    voltage-gated proton channel activity GO:0030171 ISS
    identical protein binding GO:0042802 IPI
    protein homodimerization activity GO:0042803 IDA
Biological Process
    single fertilization GO:0007338 IEA
    response to pH GO:0009268 ISS
    response to zinc ion GO:0010043 IDA
    response to zinc ion GO:0010043 ISS
    positive regulation of superoxide anion generation GO:0032930 IEA
    innate immune response GO:0045087 IEA
    cell redox homeostasis GO:0045454 TAS
    regulation of intracellular pH GO:0051453 IMP
    regulation of intracellular pH GO:0051453 ISS
    regulation of acrosome reaction GO:0060046 IDA
    cellular response to zinc ion GO:0071294 IDA
    cellular response to pH GO:0071467 IDA
    proton transmembrane transport GO:1902600 IBA
    proton transmembrane transport GO:1902600 IDA
    proton transmembrane transport GO:1902600 ISS
    regulation of reactive oxygen species biosynthetic process GO:1903426 IDA
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    membrane GO:0016020 IDA
    apical plasma membrane GO:0016324 IEA
    secretory granule membrane GO:0030667 TAS
    phagocytic vesicle membrane GO:0030670 IDA
    phagocytic vesicle membrane GO:0030670 TAS
    monoatomic ion channel complex GO:0034702 IEA
    specific granule membrane GO:0035579 TAS
    sperm flagellum GO:0036126 IDA
 Experiment description of studies that identified HVCN1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for HVCN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CHEK1  
Affinity Capture-MS Homo sapiens
2 ATG16L1 55054
Affinity Capture-MS Homo sapiens
3 DFNA5 1687
Affinity Capture-MS Homo sapiens
4 JCHAIN 3512
Affinity Capture-MS Homo sapiens
5 CST1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 DOK2 9046
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 TANK 10010
Affinity Capture-MS Homo sapiens
8 PVRL2 5819
Affinity Capture-MS Homo sapiens
9 TTYH1  
Affinity Capture-MS Homo sapiens
10 UQCC1 55245
Affinity Capture-MS Homo sapiens
11 OXLD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CST2  
Affinity Capture-MS Homo sapiens
13 ASAH1 427
Affinity Capture-MS Homo sapiens
14 VPS45 11311
Affinity Capture-MS Homo sapiens
15 KIF5B 3799
Affinity Capture-MS Homo sapiens
16 MUCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 KIF5C 3800
Affinity Capture-MS Homo sapiens
18 KLC4 89953
Affinity Capture-MS Homo sapiens
19 TBK1 29110
Affinity Capture-MS Homo sapiens
20 STXBP1 6812
Affinity Capture-MS Homo sapiens
21 FAM91A1 157769
Affinity Capture-MS Homo sapiens
22 STXBP2 6813
Affinity Capture-MS Homo sapiens
23 KLHDC10 23008
Affinity Capture-MS Homo sapiens
24 PYCRL 65263
Affinity Capture-MS Homo sapiens
25 CREB3  
Two-hybrid Homo sapiens
26 CD63 967
Affinity Capture-MS Homo sapiens
27 LMNA 4000
Affinity Capture-MS Homo sapiens
28 PIGR 5284
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
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