Gene description for KLHDC10
Gene name kelch domain containing 10
Gene symbol KLHDC10
Other names/aliases slim
Species Homo sapiens
 Database cross references - KLHDC10
ExoCarta ExoCarta_23008
Vesiclepedia VP_23008
Entrez Gene 23008
HGNC 22194
MIM 615152
UniProt Q6PID8  
 KLHDC10 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for KLHDC10
Molecular Function
    protein binding GO:0005515 IPI
    ubiquitin-like ligase-substrate adaptor activity GO:1990756 IDA
Biological Process
    protein ubiquitination GO:0016567 IEA
    positive regulation of stress-activated MAPK cascade GO:0032874 IBA
    rescue of stalled ribosome GO:0072344 IDA
    ubiquitin-dependent protein catabolic process via the C-end degron rule pathway GO:0140627 IDA
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IDA
    Cul2-RING ubiquitin ligase complex GO:0031462 IDA
 Experiment description of studies that identified KLHDC10 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for KLHDC10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 KCNH2  
Affinity Capture-MS Homo sapiens
2 LOXL1 4016
Affinity Capture-MS Homo sapiens
3 C1QTNF1 114897
Affinity Capture-MS Homo sapiens
4 MYCN  
Affinity Capture-MS Homo sapiens
5 USP7 7874
Affinity Capture-MS Homo sapiens
6 KITLG  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 Smc1a  
Affinity Capture-MS Mus musculus
8 HVCN1 84329
Affinity Capture-MS Homo sapiens
9 GLMN 11146
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RIN3  
Affinity Capture-MS Homo sapiens
11 TBC1D9  
Affinity Capture-MS Homo sapiens
12 UBXN7 26043
Affinity Capture-MS Homo sapiens
13 TRERF1  
Affinity Capture-MS Homo sapiens
14 SCRT1 83482
Affinity Capture-MS Homo sapiens
15 RAB3IL1 5866
Affinity Capture-MS Homo sapiens
16 RBX1 9978
Affinity Capture-MS Homo sapiens
17 ZNF444  
Affinity Capture-MS Homo sapiens
18 C1orf35  
Affinity Capture-MS Homo sapiens
19 PYCR1 5831
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 IKZF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 DDX58 23586
Affinity Capture-RNA Homo sapiens
22 NXF1 10482
Affinity Capture-RNA Homo sapiens
23 ZNRF2 223082
Affinity Capture-MS Homo sapiens
24 DCUN1D1 54165
Affinity Capture-MS Homo sapiens
25 MOV10 4343
Affinity Capture-RNA Homo sapiens
26 SULF2 55959
Affinity Capture-MS Homo sapiens
27 MYC  
Affinity Capture-MS Homo sapiens
28 PIK3CB 5291
Affinity Capture-MS Homo sapiens
29 RBM3 5935
Affinity Capture-MS Homo sapiens
30 SH3GLB1 51100
Affinity Capture-MS Homo sapiens
31 GIGYF1  
Affinity Capture-MS Homo sapiens
32 PRKD1 5587
Affinity Capture-MS Homo sapiens
33 NACC2  
Affinity Capture-MS Homo sapiens
34 DEFA5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 PYCRL 65263
Affinity Capture-MS Homo sapiens
36 TCEB2 6923
Affinity Capture-MS Homo sapiens
37 CERS6  
Affinity Capture-MS Homo sapiens
38 SLC31A1 1317
Affinity Capture-MS Homo sapiens
39 CUL2 8453
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 LEMD3  
Affinity Capture-MS Homo sapiens
41 POTEG  
Affinity Capture-MS Homo sapiens
42 HSPB8 26353
Affinity Capture-MS Homo sapiens
43 NEDD8 4738
Affinity Capture-MS Homo sapiens
44 NUDCD3 23386
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which KLHDC10 is involved
No pathways found





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