Gene description for TBK1
Gene name	TANK-binding kinase 1
Gene symbol	TBK1
Other names/aliases	NAK T2K
Species	Homo sapiens
Database cross references - TBK1
ExoCarta	ExoCarta_29110
Entrez Gene	29110
HGNC	11584
MIM	604834
UniProt	Q9UHD2
TBK1 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Colorectal cancer cells	23161513
Thymus	23844026

Gene ontology annotations for TBK1

Molecular Function     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     phosphoprotein binding GO:0051219 IPI     protein kinase activity GO:0004672 NAS     protein serine/threonine kinase activity GO:0004674 TAS     nucleic acid binding GO:0003676 IEA Biological Process     positive regulation of peptidyl-serine phosphorylation GO:0033138 NAS     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IDA     toll-like receptor 4 signaling pathway GO:0034142 TAS     TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS     inflammatory response GO:0006954 TAS     defense response to virus GO:0051607 IEA     toll-like receptor 3 signaling pathway GO:0034138 TAS     dendritic cell proliferation GO:0044565 IEA     I-kappaB kinase/NF-kappaB signaling GO:0007249 TAS     MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS     positive regulation of type I interferon production GO:0032481 TAS     negative regulation of type I interferon production GO:0032480 TAS     protein phosphorylation GO:0006468 IEA     positive regulation of interferon-beta biosynthetic process GO:0045359 IEA     response to virus GO:0009615 TAS     type I interferon production GO:0032606 TAS     positive regulation of interferon-alpha production GO:0032727 IDA     positive regulation of interferon-beta production GO:0032728 IDA     negative regulation of gene expression GO:0010629 IEA     toll-like receptor signaling pathway GO:0002224 TAS     positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP     defense response to Gram-positive bacterium GO:0050830 IEA     viral process GO:0016032 IEA     innate immune response GO:0045087 TAS Subcellular Localization     endosome membrane GO:0010008 TAS     cytoplasm GO:0005737 IDA     cytosol GO:0005829 TAS