Gene description for HSP90AA2P
Gene name heat shock protein 90kDa alpha (cytosolic), class A member 2, pseudogene
Gene symbol HSP90AA2P
Other names/aliases HSP90AA2
HSP90ALPHA
HSPCA
HSPCAL3
Species Homo sapiens
 Database cross references - HSP90AA2P
ExoCarta ExoCarta_3324
Vesiclepedia VP_3324
Entrez Gene 3324
HGNC 5256
MIM 140575
 HSP90AA2P identified in sEVs derived from the following tissue/cell type
Colorectal cancer cells 17956143    
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for HSP90AA2P
Molecular Function
    ATP binding GO:0005524 IBA
    ATP hydrolysis activity GO:0016887 IBA
    unfolded protein binding GO:0051082 IBA
    ATP-dependent protein folding chaperone GO:0140662 IEA
Biological Process
    protein folding GO:0006457 IBA
    cellular response to heat GO:0034605 IBA
    protein stabilization GO:0050821 IBA
Subcellular Localization
    cytosol GO:0005829 IBA
    plasma membrane GO:0005886 IBA
    protein-containing complex GO:0032991 IBA
    perinuclear region of cytoplasm GO:0048471 IBA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified HSP90AA2P in sEVs
1
Experiment ID 20
MISEV standards
EM
Biophysical techniques
HSP90|CD63|CD81|LAMP1
Enriched markers
GOLGA2|cytochrome c
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors "Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS"
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 126
MISEV standards
Biophysical techniques
GAPDH
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for HSP90AA2P
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ANLN 54443
Affinity Capture-MS Homo sapiens
2 GPN1  
Affinity Capture-MS Homo sapiens
3 CUL1 8454
Affinity Capture-MS Homo sapiens
4 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
5 MAP3K1 4214
Affinity Capture-MS Homo sapiens
6 KIF14 9928
Affinity Capture-MS Homo sapiens
7 RUVBL2 10856
Affinity Capture-MS Homo sapiens
8 CHMP4C 92421
Affinity Capture-MS Homo sapiens
9 IKBKG 8517
Affinity Capture-MS Homo sapiens
10 CUL3 8452
Affinity Capture-MS Homo sapiens
11 KIF20A 10112
Affinity Capture-MS Homo sapiens
12 HSP90AB1 3326
Co-fractionation Homo sapiens
13 USP11 8237
Affinity Capture-MS Homo sapiens
14 ECT2 1894
Affinity Capture-MS Homo sapiens
15 CUL4B 8450
Affinity Capture-MS Homo sapiens
16 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
17 CAND1 55832
Affinity Capture-MS Homo sapiens
18 AURKB 9212
Affinity Capture-MS Homo sapiens
19 TBK1 29110
Affinity Capture-MS Homo sapiens
20 PLD2 5338
Affinity Capture-MS Homo sapiens
21 CHMP4B 128866
Affinity Capture-MS Homo sapiens
22 BAG1 573
Affinity Capture-MS Homo sapiens
23 KIF23 9493
Affinity Capture-MS Homo sapiens
24 COPS6 10980
Affinity Capture-MS Homo sapiens
25 RPAP3 79657
Affinity Capture-MS Homo sapiens
26 COPS5 10987
Affinity Capture-MS Homo sapiens
27 PRC1 9055
Affinity Capture-MS Homo sapiens
28 ZC3HAV1 56829
Affinity Capture-MS Homo sapiens
29 CUL2 8453
Affinity Capture-MS Homo sapiens
30 HSPA9 3313
Co-fractionation Homo sapiens
31 MAP3K3 4215
Affinity Capture-MS Homo sapiens
32 IKBKE 9641
Affinity Capture-MS Homo sapiens
33 CYLD  
Affinity Capture-MS Homo sapiens
34 NEDD8 4738
Affinity Capture-MS Homo sapiens
35 EP300 2033
Reconstituted Complex Homo sapiens
Biochemical Activity Homo sapiens
36 CUL5 8065
Affinity Capture-MS Homo sapiens
37 TRAF1 7185
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which HSP90AA2P is involved
No pathways found





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