Gene description for IKBKE
Gene name inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
Gene symbol IKBKE
Other names/aliases IKK-E
IKK-i
IKKE
IKKI
Species Homo sapiens
 Database cross references - IKBKE
ExoCarta ExoCarta_9641
Vesiclepedia VP_9641
Entrez Gene 9641
HGNC 14552
MIM 605048
UniProt Q14164  
 IKBKE identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IKBKE
Molecular Function
    protein binding GO:0005515 IPI
    IkappaB kinase activity GO:0008384 IEA
    ATP binding GO:0005524 IEA
    NF-kappaB-inducing kinase activity GO:0004704 IDA
Biological Process
    negative regulation of type I interferon production GO:0032480 TAS
    toll-like receptor signaling pathway GO:0002224 TAS
    innate immune response GO:0045087 TAS
    toll-like receptor 3 signaling pathway GO:0034138 TAS
    I-kappaB phosphorylation GO:0007252 IEA
    immune response GO:0006955 NAS
    protein phosphorylation GO:0006468 IDA
    toll-like receptor 4 signaling pathway GO:0034142 TAS
    NIK/NF-kappaB signaling GO:0038061 IDA
    TRIF-dependent toll-like receptor signaling pathway GO:0035666 TAS
    intrinsic apoptotic signaling pathway in response to DNA damage GO:0008630 IMP
    MyD88-independent toll-like receptor signaling pathway GO:0002756 TAS
    positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 IEP
Subcellular Localization
    mitochondrial membrane GO:0031966 IMP
    cytoplasm GO:0005737 IDA
    PML body GO:0016605 IDA
    nucleus GO:0005634 IDA
    endosome membrane GO:0010008 TAS
    nucleoplasm GO:0005654 IDA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified IKBKE in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IKBKE
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TANK 10010
Invivo Homo sapiens
Two-hybrid Homo sapiens
2 PLS3 5358
Affinity Capture-MS Homo sapiens
3 ACLY 47
Affinity Capture-MS Homo sapiens
4 RUVBL2 10856
Affinity Capture-MS Homo sapiens
5 DSTYK 25778
Affinity Capture-MS Homo sapiens
6 CDC37 11140
Affinity Capture-MS Homo sapiens
7 ROCK2 9475
Affinity Capture-MS Homo sapiens
8 EPRS 2058
Affinity Capture-MS Homo sapiens
9 LARS 51520
Affinity Capture-MS Homo sapiens
10 LRPPRC 10128
Affinity Capture-MS Homo sapiens
11 FKBP5 2289
Affinity Capture-MS Homo sapiens
12 PABPC1 26986
Affinity Capture-MS Homo sapiens
13 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
14 VCP 7415
Affinity Capture-MS Homo sapiens
15 PSMA7 5688
Affinity Capture-MS Homo sapiens
16 HSP90AA2P 3324
Affinity Capture-MS Homo sapiens
17 IMPDH2 3615
Affinity Capture-MS Homo sapiens
18 HYOU1 10525
Affinity Capture-MS Homo sapiens
19 MYH10 4628
Affinity Capture-MS Homo sapiens
20 KTN1 3895
Affinity Capture-MS Homo sapiens
21 CLTC 1213
Affinity Capture-MS Homo sapiens
22 SND1 27044
Affinity Capture-MS Homo sapiens
23 ATIC 471
Affinity Capture-MS Homo sapiens
24 PDIA6 10130
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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