Gene description for MAVS
Gene name mitochondrial antiviral signaling protein
Gene symbol MAVS
Other names/aliases CARDIF
IPS-1
IPS1
VISA
Species Homo sapiens
 Database cross references - MAVS
ExoCarta ExoCarta_57506
Vesiclepedia VP_57506
Entrez Gene 57506
HGNC 29233
MIM 609676
UniProt Q7Z434  
 MAVS identified in sEVs derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for MAVS
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IPI
    signaling adaptor activity GO:0035591 IDA
    signaling adaptor activity GO:0035591 IMP
    RIG-I binding GO:0039552 IDA
    identical protein binding GO:0042802 IDA
    CARD domain binding GO:0050700 IPI
    molecular adaptor activity GO:0060090 IDA
    molecular condensate scaffold activity GO:0140693 IDA
Biological Process
    positive regulation of protein phosphorylation GO:0001934 IDA
    activation of innate immune response GO:0002218 IDA
    activation of innate immune response GO:0002218 IMP
    positive regulation of defense response to virus by host GO:0002230 IDA
    positive regulation of defense response to virus by host GO:0002230 IMP
    positive regulation of myeloid dendritic cell cytokine production GO:0002735 ISS
    cytoplasmic pattern recognition receptor signaling pathway GO:0002753 IDA
    signal transduction GO:0007165 IMP
    positive regulation of type I interferon production GO:0032481 IDA
    positive regulation of interferon-alpha production GO:0032727 IDA
    positive regulation of interferon-alpha production GO:0032727 IMP
    positive regulation of interferon-beta production GO:0032728 IDA
    positive regulation of interferon-beta production GO:0032728 IMP
    positive regulation of interleukin-6 production GO:0032755 IMP
    positive regulation of interleukin-8 production GO:0032757 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IDA
    positive regulation of tumor necrosis factor production GO:0032760 IMP
    positive regulation of protein import into nucleus GO:0042307 IDA
    defense response to bacterium GO:0042742 IMP
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 HMP
    negative regulation of viral genome replication GO:0045071 IDA
    innate immune response GO:0045087 IDA
    innate immune response GO:0045087 IMP
    positive regulation of transcription by RNA polymerase II GO:0045944 IDA
    positive regulation of DNA-binding transcription factor activity GO:0051091 IDA
    defense response to virus GO:0051607 IDA
    defense response to virus GO:0051607 NAS
    type I interferon-mediated signaling pathway GO:0060337 NAS
    negative regulation of type I interferon-mediated signaling pathway GO:0060339 IMP
    positive regulation of type I interferon-mediated signaling pathway GO:0060340 IDA
    positive regulation of response to cytokine stimulus GO:0060760 IMP
    protein localization to mitochondrion GO:0070585 IDA
    cellular response to exogenous dsRNA GO:0071360 IMP
    positive regulation of chemokine (C-C motif) ligand 5 production GO:0071651 IDA
    positive regulation of IP-10 production GO:0071660 IDA
    antiviral innate immune response GO:0140374 IDA
    regulation of peroxisome organization GO:1900063 IMP
    positive regulation of NLRP3 inflammasome complex assembly GO:1900227 IDA
Subcellular Localization
    ubiquitin ligase complex GO:0000151 NAS
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 TAS
    peroxisomal membrane GO:0005778 IDA
    mitochondrial membrane GO:0031966 IDA
    mitochondrial membrane GO:0031966 IDA
 Experiment description of studies that identified MAVS in sEVs
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
4
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MAVS
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 LY86  
Affinity Capture-MS Homo sapiens
3 REC8  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
4 SLC39A12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 TRAF3IP3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
6 AFG3L2 10939
Proximity Label-MS Homo sapiens
7 FAM73A  
Proximity Label-MS Homo sapiens
8 MTCH1 23787
Proximity Label-MS Homo sapiens
9 MARCKS 4082
Proximity Label-MS Homo sapiens
10 IFIH1  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
11 DHRS9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 KCTD10 83892
Affinity Capture-MS Homo sapiens
13 BZW2 28969
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 RAB35 11021
Proximity Label-MS Homo sapiens
15 RARRES3  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
16 CISD1 55847
Proximity Label-MS Homo sapiens
17 ZDHHC4  
Affinity Capture-MS Homo sapiens
18 UBE4A 9354
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
19 PPIA 5478
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
20 PTPN1 5770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
21 RNF34  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Far Western Homo sapiens
22 SOX9  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
23 TLR1 7096
Affinity Capture-MS Homo sapiens
24 KCNIP3  
Two-hybrid Homo sapiens
25 VANGL2  
Affinity Capture-Western Homo sapiens
26 FIS1 51024
Proximity Label-MS Homo sapiens
27 HEATR3 55027
Affinity Capture-MS Homo sapiens
28 RNF5  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
29 WDR41  
Proximity Label-MS Homo sapiens
30 DYNC1LI2 1783
Proximity Label-MS Homo sapiens
31 COQ9  
Affinity Capture-MS Homo sapiens
32 COPS6 10980
Affinity Capture-Western Homo sapiens
33 RAB3B 5865
Proximity Label-MS Homo sapiens
34 TRABD 80305
Proximity Label-MS Homo sapiens
35 SRC 6714
Affinity Capture-Western Homo sapiens
36 ABCD3 5825
Proximity Label-MS Homo sapiens
37 OTUB2  
Affinity Capture-Western Homo sapiens
38 IFIT3 3437
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
39 MARCH5  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
40 VPS13D 55187
Proximity Label-MS Homo sapiens
41 OTUD7B 56957
Affinity Capture-Western Homo sapiens
42 IKBKE 9641
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
43 EXD2  
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
44 ZC3HAV1 56829
Proximity Label-MS Homo sapiens
45 SLC25A46 91137
Proximity Label-MS Homo sapiens
46 HYPM  
Affinity Capture-MS Homo sapiens
47 RIPK2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
48 USP2  
Affinity Capture-Western Homo sapiens
49 MAVS 57506
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
50 RAB6B 51560
Affinity Capture-MS Homo sapiens
51 WDR5 11091
Affinity Capture-Western Homo sapiens
52 FAF2 23197
Proximity Label-MS Homo sapiens
53 SOD1 6647
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 PSMC3 5702
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
55 GPR17 2840
Affinity Capture-MS Homo sapiens
56 ATG5 9474
Affinity Capture-Western Homo sapiens
57 TDRKH  
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
58 BAG6 7917
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
59 HSPA8 3312
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
60 ADSL 158
Proximity Label-MS Homo sapiens
61 USP22 23326
Affinity Capture-Western Homo sapiens
62 NUP155 9631
Proximity Label-MS Homo sapiens
63 NDFIP1 80762
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
64 PXMP2  
Proximity Label-MS Homo sapiens
65 HSPBP1 23640
Affinity Capture-MS Homo sapiens
66 RAB5A 5868
Proximity Label-MS Homo sapiens
67 Trim31  
Biochemical Activity Mus musculus
68 EIF2AK2 5610
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
69 MTCH2 23788
Proximity Label-MS Homo sapiens
70 USP12 219333
Affinity Capture-Western Homo sapiens
71 SAMM50 25813
Proximity Label-MS Homo sapiens
72 GCGR  
Affinity Capture-MS Homo sapiens
73 AMFR 267
Affinity Capture-Western Homo sapiens
74 NBR1 4077
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
75 DNAH17 8632
Affinity Capture-MS Homo sapiens
76 OPTN 10133
Affinity Capture-Western Homo sapiens
77 NLRX1 79671
Affinity Capture-Western Homo sapiens
78 MAPRE1 22919
Proximity Label-MS Homo sapiens
79 PSMD14 10213
Affinity Capture-Western Homo sapiens
80 RNF115  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
81 RAB4A 5867
Proximity Label-MS Homo sapiens
82 IRF7  
Affinity Capture-Western Homo sapiens
83 DIABLO 56616
Proximity Label-MS Homo sapiens
84 TRIM14 9830
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
85 CDH1 999
Proximity Label-MS Homo sapiens
86 IRF3 3661
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
87 C9orf72  
Proximity Label-MS Homo sapiens
88 PDS5A 23244
Affinity Capture-MS Homo sapiens
89 TRIM21 6737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
90 RNF166  
Affinity Capture-Western Homo sapiens
91 DHX16 8449
Affinity Capture-Western Homo sapiens
92 OPA1 4976
Proximity Label-MS Homo sapiens
93 PLK1 5347
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
94 JOSD2  
Affinity Capture-Western Homo sapiens
95 PEX14 5195
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
96 RAB7A 7879
Proximity Label-MS Homo sapiens
97 OAS3 4940
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
98 MB21D1  
Affinity Capture-Western Homo sapiens
99 CSNK1E 1454
Affinity Capture-Western Homo sapiens
100 NXPE2  
Affinity Capture-MS Homo sapiens
101 DNM2 1785
Affinity Capture-MS Homo sapiens
102 FLOT2 2319
Co-fractionation Homo sapiens
103 RHOT2 89941
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
104 MFF 56947
Proximity Label-MS Homo sapiens
105 ARMCX2 9823
Proximity Label-MS Homo sapiens
106 PRKACB 5567
Affinity Capture-Western Homo sapiens
107 CYLD  
Affinity Capture-Western Homo sapiens
108 BIRC3 330
Affinity Capture-Western Homo sapiens
109 PIPSL 266971
Affinity Capture-MS Homo sapiens
110 SLC7A1 6541
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 MAP4K1  
Affinity Capture-Western Homo sapiens
112 PCBP2 5094
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
113 CISD3 284106
Affinity Capture-MS Homo sapiens
114 PSMA7 5688
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
115 BIRC2  
Affinity Capture-Western Homo sapiens
116 VIPR2  
Affinity Capture-MS Homo sapiens
117 SMCR8 140775
Proximity Label-MS Homo sapiens
118 HSD3B7 80270
Proximity Label-MS Homo sapiens
119 CALCOCO2  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
120 USP4 7375
Affinity Capture-Western Homo sapiens
121 AIFM1 9131
Proximity Label-MS Homo sapiens
122 TRIM31  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
123 TAX1BP1 8887
Affinity Capture-Western Homo sapiens
124 MARCH1  
Affinity Capture-Western Homo sapiens
125 CDCA3 83461
Proximity Label-MS Homo sapiens
126 BAG2 9532
Affinity Capture-MS Homo sapiens
127 MTX2 10651
Proximity Label-MS Homo sapiens
128 PRKAR2A 5576
Proximity Label-MS Homo sapiens
129 ATG12  
Affinity Capture-Western Homo sapiens
130 TRAF6 7189
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Co-crystal Structure Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
131 CNTN1 1272
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
132 FKBP8 23770
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
133 MYO19  
Proximity Label-MS Homo sapiens
134 NUP43 348995
Proximity Label-MS Homo sapiens
135 NACC1 112939
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
136 SERINC5 256987
Affinity Capture-Western Homo sapiens
137 KPTN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
138 TRAF3 7187
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
139 TMEM169  
Affinity Capture-MS Homo sapiens
140 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
141 FADD 8772
Affinity Capture-Western Homo sapiens
142 TOMM70A 9868
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
143 GK  
Proximity Label-MS Homo sapiens
144 TMEM173  
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
145 PRKACA 5566
Affinity Capture-Western Homo sapiens
146 CHRNA9  
Affinity Capture-MS Homo sapiens
147 STAT1 6772
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
148 IFIT1 3434
Proximity Label-MS Homo sapiens
149 IRF5  
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
150 DYNC1LI1 51143
Proximity Label-MS Homo sapiens
151 SNX8 29886
Affinity Capture-Western Homo sapiens
152 FBXL4 26235
Proximity Label-MS Homo sapiens
153 RAB9A 9367
Proximity Label-MS Homo sapiens
154 TRAF5  
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
155 RPL35A 6165
Affinity Capture-MS Homo sapiens
156 USP19 10869
Affinity Capture-Western Homo sapiens
157 SH3GLB2 56904
Proximity Label-MS Homo sapiens
158 PEX5 5830
Proximity Label-MS Homo sapiens
159 MFN2 9927
Proximity Label-MS Homo sapiens
160 SGTA 6449
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
161 TRIM40 135644
Affinity Capture-Western Homo sapiens
162 TRIM28 10155
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
163 HAX1  
Proximity Label-MS Homo sapiens
164 MAP3K7  
Affinity Capture-Western Homo sapiens
165 HSPA9 3313
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 GPR113  
Affinity Capture-MS Homo sapiens
167 PEX3 8504
Proximity Label-MS Homo sapiens
168 AKAP1 8165
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
169 UBXN1 51035
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
170 TICAM1  
Affinity Capture-Western Homo sapiens
171 ACBD5 91452
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
172 EIF3H 8667
Affinity Capture-Western Homo sapiens
173 AVPR2  
Affinity Capture-MS Homo sapiens
174 USP46 64854
Affinity Capture-Western Homo sapiens
175 PHB2 11331
Proximity Label-MS Homo sapiens
176 MUL1  
Affinity Capture-Western Homo sapiens
177 TRAF2 7186
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-Western Homo sapiens
178 UBXN4 23190
Proximity Label-MS Homo sapiens
179 USP25  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
180 USP29  
Affinity Capture-Western Homo sapiens
181 VAC14 55697
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
182 PDCL 5082
Proximity Label-MS Homo sapiens
183 HECTD3 79654
Affinity Capture-MS Homo sapiens
184 DDX3X 1654
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
185 USP35  
Affinity Capture-Western Homo sapiens
186 IKBKG 8517
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
187 SMURF1 57154
Affinity Capture-Western Homo sapiens
188 SQSTM1 8878
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
189 ABL1 25
Affinity Capture-Western Homo sapiens
Far Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
190 ITCH 83737
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
191 OTUB1 55611
Affinity Capture-Western Homo sapiens
192 DDX58 23586
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
193 PRKAR2B 5577
Proximity Label-MS Homo sapiens
194 TRIM25 7706
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
195 SFXN1 94081
Proximity Label-MS Homo sapiens
196 TBK1 29110
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
197 KRR1 11103
Affinity Capture-Western Homo sapiens
198 USP30  
Proximity Label-MS Homo sapiens
199 DNM1L 10059
Proximity Label-MS Homo sapiens
200 MAP1LC3A 84557
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
201 OTUD4  
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
202 BCL2L13 23786
Proximity Label-MS Homo sapiens
203 USP28 57646
Affinity Capture-Western Homo sapiens
204 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
205 TSPAN6 7105
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
206 SLC25A51  
Proximity Label-MS Homo sapiens
207 RAB11A 8766
Proximity Label-MS Homo sapiens
208 YKT6 10652
Proximity Label-MS Homo sapiens
209 MIB2 142678
Affinity Capture-MS Homo sapiens
210 RAB5C 5878
Proximity Label-MS Homo sapiens
211 GNB2L1 10399
Affinity Capture-Western Homo sapiens
212 INSC  
Affinity Capture-MS Homo sapiens
213 SMURF2 64750
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
214 RMDN3 55177
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
215 C19orf52  
Proximity Label-MS Homo sapiens
216 RPA3 6119
Proximity Label-MS Homo sapiens
217 ECSIT 51295
Affinity Capture-Western Homo sapiens
218 TRAF1 7185
Affinity Capture-Western Homo sapiens
219 HSPA2 3306
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which MAVS is involved
PathwayEvidenceSource
Antiviral mechanism by IFN-stimulated genes TAS Reactome
Cytokine Signaling in Immune system TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta TAS Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta IEA Reactome
Deubiquitination TAS Reactome
Disease TAS Reactome
Evasion by RSV of host interferon responses TAS Reactome
Immune System TAS Reactome
Immune System IEA Reactome
Infectious disease TAS Reactome
Innate Immune System TAS Reactome
Innate Immune System IEA Reactome
Interferon Signaling TAS Reactome
Metabolism of proteins TAS Reactome
Negative regulators of DDX58/IFIH1 signaling TAS Reactome
Negative regulators of DDX58/IFIH1 signaling IEA Reactome
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 TAS Reactome
Ovarian tumor domain proteases TAS Reactome
PKR-mediated signaling TAS Reactome
Post-translational protein modification TAS Reactome
Respiratory Syncytial Virus Infection Pathway TAS Reactome
RSV-host interactions TAS Reactome
SARS-CoV Infections TAS Reactome
SARS-CoV-1 activates/modulates innate immune responses TAS Reactome
SARS-CoV-1 Infection TAS Reactome
SARS-CoV-1-host interactions TAS Reactome
SARS-CoV-2 activates/modulates innate and adaptive immune responses TAS Reactome
SARS-CoV-2 Infection TAS Reactome
SARS-CoV-2-host interactions TAS Reactome
TRAF3-dependent IRF activation pathway TAS Reactome
TRAF6 mediated IRF7 activation TAS Reactome
TRAF6 mediated NF-kB activation TAS Reactome
TRAF6 mediated NF-kB activation IEA Reactome
Viral Infection Pathways TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here