Gene description for CNTN1
Gene name contactin 1
Gene symbol CNTN1
Other names/aliases F3
GP135
MYPCN
Species Homo sapiens
 Database cross references - CNTN1
ExoCarta ExoCarta_1272
Entrez Gene 1272
HGNC 2171
MIM 600016
UniProt Q12860  
 CNTN1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Prostate cancer cells 25844599    
 Gene ontology annotations for CNTN1
Molecular Function
    glycoprotein binding GO:0001948 IEA
    carbohydrate binding GO:0030246 IEA
Biological Process
    axon guidance GO:0007411 TAS
    Notch signaling pathway GO:0007219 TAS
    positive regulation of sodium ion transport GO:0010765 IEA
    positive regulation of gene expression GO:0010628 IEA
    cell adhesion GO:0007155 IEA
    cerebellum development GO:0021549 IEA
    positive regulation of neuron projection development GO:0010976 IEA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 IDA
    membrane GO:0016020 TAS
    anchored component of membrane GO:0031225 IEA
 Experiment description of studies that identified CNTN1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 275
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for CNTN1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PTPRB 5787
Invivo Homo sapiens
Invivo Homo sapiens
2 L1CAM 3897
Invivo Homo sapiens
3 TNR  
Invivo Homo sapiens
Invivo Homo sapiens
4 PTPRZ1  
Affinity Capture-Western Homo sapiens
5 ANK3  
Affinity Capture-Western Homo sapiens
6 SCN1B  
Affinity Capture-Western Homo sapiens
7 FYN 2534
Invivo Homo sapiens
8 NOTCH1 4851
Affinity Capture-Western Homo sapiens
9 TNC 3371
Invivo Homo sapiens
10 NOTCH2 4853
Affinity Capture-Western Homo sapiens
11 CNTN2  
Invitro Homo sapiens
View the network image/svg+xml



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