Gene description for TRIM40
Gene name tripartite motif containing 40
Gene symbol TRIM40
Other names/aliases RNF35
Species Homo sapiens
 Database cross references - TRIM40
ExoCarta ExoCarta_135644
Entrez Gene 135644
HGNC 18736
UniProt Q6P9F5  
 TRIM40 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells Unpublished / Not applicable
 Gene ontology annotations for TRIM40
Molecular Function
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
Biological Process
    negative regulation of NIK/NF-kappaB signaling GO:1901223 NAS
    protein neddylation GO:0045116 IDA
    negative regulation of cell growth GO:0030308 IEA
    negative regulation of protein catabolic process GO:0042177 IDA
    negative regulation of protein localization to nucleus GO:1900181 IDA
    negative regulation of NF-kappaB transcription factor activity GO:0032088 IDA
Subcellular Localization
    IkappaB kinase complex GO:0008385 IDA
 Experiment description of studies that identified TRIM40 in exosomes
1
Experiment ID 126
ISEV standards
✘ EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✘ EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
 Protein-protein interactions for TRIM40
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which TRIM40 is involved
No pathways found





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