Gene description for NACC1
Gene name nucleus accumbens associated 1, BEN and BTB (POZ) domain containing
Gene symbol NACC1
Other names/aliases BEND8
BTBD14B
BTBD30
NAC-1
NAC1
Species Homo sapiens
 Database cross references - NACC1
ExoCarta ExoCarta_112939
Vesiclepedia VP_112939
Entrez Gene 112939
HGNC 20967
MIM 610672
UniProt Q96RE7  
 NACC1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for NACC1
Molecular Function
    RNA polymerase II regulatory region sequence-specific DNA binding GO:0000977 IBA
    RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001227 IBA
Biological Process
    negative regulation of transcription, DNA-templated GO:0045892 IMP
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IBA
    positive regulation of cell proliferation GO:0008284 IMP
    transcription, DNA-templated GO:0006351 IEA
    protein homooligomerization GO:0051260 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    nucleoplasm GO:0005654 IDA
    nucleus GO:0005634 IDA
    intracellular membrane-bounded organelle GO:0043231 IDA
    nuclear body GO:0016604 IDA
    cell junction GO:0030054 IDA
 Experiment description of studies that identified NACC1 in exosomes
1
Experiment ID 235
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for NACC1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which NACC1 is involved
No pathways found





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