Gene description for DTX4
Gene name deltex 4, E3 ubiquitin ligase
Gene symbol DTX4
Other names/aliases RNF155
Species Homo sapiens
 Database cross references - DTX4
ExoCarta ExoCarta_23220
Vesiclepedia VP_23220
Entrez Gene 23220
HGNC 29151
MIM 616110
UniProt Q9Y2E6  
 DTX4 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 34887515    
 Gene ontology annotations for DTX4
Molecular Function
    ligase activity GO:0016874 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    positive regulation of type I interferon production GO:0032481 TAS
    regulation of type I interferon production GO:0032479 TAS
    innate immune response GO:0045087 TAS
    Notch signaling pathway GO:0007219 IEA
    protein ubiquitination GO:0016567 IEA
Subcellular Localization
    cytosol GO:0005829 TAS
 Experiment description of studies that identified DTX4 in exosomes
1
Experiment ID 1203
MISEV standards
✔
EM
EV Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ.
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
 Protein-protein interactions for DTX4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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