Gene description for FAT4
Gene name FAT atypical cadherin 4
Gene symbol FAT4
Other names/aliases CDHF14
CDHR11
FAT-J
FATJ
HKLLS2
NBLA00548
VMLDS2
Species Homo sapiens
 Database cross references - FAT4
ExoCarta ExoCarta_79633
Vesiclepedia VP_79633
Entrez Gene 79633
HGNC 23109
MIM 612411
UniProt Q6V0I7  
 FAT4 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells Unpublished / Not applicable
Prostate cancer cells 25844599    
 Gene ontology annotations for FAT4
Molecular Function
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
Biological Process
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007157 ISS
    cerebral cortex development GO:0021987 ISS
    neurogenesis GO:0022008 ISS
    hippo signaling GO:0035329 ISS
    cell-cell adhesion GO:0098609 IBA
Subcellular Localization
    plasma membrane GO:0005886 IEA
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified FAT4 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
6
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for FAT4
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ATXN1 6310
Two-hybrid Homo sapiens
2 CSTL1  
Affinity Capture-MS Homo sapiens
3 FBXO45 200933
Affinity Capture-MS Homo sapiens
4 C2CD4B  
Affinity Capture-MS Homo sapiens
5 PCDHGB1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 ZBBX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 SIRT6  
Affinity Capture-MS Homo sapiens
8 PPIAL4G  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 PDGFB  
Affinity Capture-MS Homo sapiens
10 C2orf48  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 LGALS1 3956
Affinity Capture-MS Homo sapiens
12 LIX1L 128077
Affinity Capture-MS Homo sapiens
13 C7orf34  
Affinity Capture-MS Homo sapiens
14 CMA1  
Affinity Capture-MS Homo sapiens
15 LINC01588  
Affinity Capture-MS Homo sapiens
16 DNA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CARD16  
Affinity Capture-MS Homo sapiens
18 SOCS1  
Affinity Capture-MS Homo sapiens
19 CC2D1B 200014
Affinity Capture-MS Homo sapiens
20 RYK 6259
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 CX3CL1  
Affinity Capture-MS Homo sapiens
22 SPSB4  
Affinity Capture-MS Homo sapiens
23 NR3C1 2908
Proximity Label-MS Homo sapiens
24 IFNE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 LOC254896  
Affinity Capture-MS Homo sapiens
26 ADAMTS13 11093
Affinity Capture-MS Homo sapiens
27 DCANP1  
Affinity Capture-MS Homo sapiens
28 CEACAM21  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 CLU 1191
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 SHMT2 6472
Affinity Capture-RNA Homo sapiens
31 B4GALT2  
Affinity Capture-MS Homo sapiens
32 NPPB  
Affinity Capture-MS Homo sapiens
33 NXF1 10482
Affinity Capture-RNA Homo sapiens
34 DDX39A 10212
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
35 DCDC2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 UCN3  
Affinity Capture-MS Homo sapiens
37 DTX4 23220
Affinity Capture-MS Homo sapiens
38 PRSS37  
Affinity Capture-MS Homo sapiens
39 XCL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 RPL23 9349
Affinity Capture-MS Homo sapiens
41 NXPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 FAM19A5 25817
Affinity Capture-MS Homo sapiens
43 XAGE1B  
Affinity Capture-MS Homo sapiens
44 RPL28 6158
Affinity Capture-MS Homo sapiens
45 CD160  
Affinity Capture-MS Homo sapiens
46 HYOU1 10525
Affinity Capture-MS Homo sapiens
47 ENO1 2023
Affinity Capture-RNA Homo sapiens
48 NUP210P1  
Affinity Capture-MS Homo sapiens
49 RPS14P3  
Affinity Capture-MS Homo sapiens
50 DCDC1  
Affinity Capture-MS Homo sapiens
51 CCL19  
Affinity Capture-MS Homo sapiens
52 HIST1H3A 8350
Cross-Linking-MS (XL-MS) Homo sapiens
53 RPS15A 6210
Affinity Capture-MS Homo sapiens
54 CEACAM8 1088
Affinity Capture-MS Homo sapiens
55 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 DKKL1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 TCF15  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAT4 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here