Gene description for FAM19A5
Gene name family with sequence similarity 19 (chemokine (C-C motif)-like), member A5
Gene symbol FAM19A5
Other names/aliases QLLK5208
TAFA-5
TAFA5
UNQ5208
Species Homo sapiens
 Database cross references - FAM19A5
ExoCarta ExoCarta_25817
Vesiclepedia VP_25817
Entrez Gene 25817
HGNC 21592
UniProt Q7Z5A7  
 FAM19A5 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for FAM19A5
Molecular Function
    G protein-coupled receptor binding GO:0001664 IBA
    G protein-coupled receptor binding GO:0001664 IPI
    cytokine activity GO:0005125 IEA
    receptor ligand activity GO:0048018 IBA
    receptor ligand activity GO:0048018 IPI
Biological Process
    G protein-coupled receptor signaling pathway GO:0007186 IBA
    G protein-coupled receptor signaling pathway GO:0007186 IDA
    negative regulation of vascular wound healing GO:0061044 IEA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IDA
    negative regulation of vascular associated smooth muscle cell proliferation GO:1904706 IMP
    negative regulation of vascular associated smooth muscle cell migration GO:1904753 IEA
Subcellular Localization
    extracellular space GO:0005615 IBA
    extracellular space GO:0005615 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified FAM19A5 in exosomes
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for FAM19A5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DCBLD2 131566
Affinity Capture-MS Homo sapiens
2 SDK2 54549
Affinity Capture-MS Homo sapiens
3 FAT4 79633
Affinity Capture-MS Homo sapiens
4 GPR37  
Two-hybrid Homo sapiens
5 PLTP 5360
Affinity Capture-MS Homo sapiens
6 NEBL 10529
Affinity Capture-MS Homo sapiens
7 VWDE  
Affinity Capture-MS Homo sapiens
8 FREM2 341640
Affinity Capture-MS Homo sapiens
9 LRRC4B  
Affinity Capture-MS Homo sapiens
10 TMEM67 91147
Affinity Capture-MS Homo sapiens
11 LNPEP 4012
Affinity Capture-MS Homo sapiens
12 RNF167 26001
Reconstituted Complex Homo sapiens
13 ADGRV1 84059
Affinity Capture-MS Homo sapiens
14 TENM3 55714
Affinity Capture-MS Homo sapiens
15 ASPH 444
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which FAM19A5 is involved
No pathways found





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