Gene description for ADGRV1
Gene name adhesion G protein-coupled receptor V1
Gene symbol ADGRV1
Other names/aliases FEB4
GPR98
MASS1
USH2B
USH2C
VLGR1
VLGR1b
Species Homo sapiens
 Database cross references - ADGRV1
ExoCarta ExoCarta_84059
Vesiclepedia VP_84059
Entrez Gene 84059
HGNC 17416
MIM 602851
UniProt Q8WXG9  
 ADGRV1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Urine 19056867    
 Gene ontology annotations for ADGRV1
Molecular Function
    G-protein alpha-subunit binding GO:0001965 IBA
    G-protein alpha-subunit binding GO:0001965 ISS
    G protein-coupled receptor activity GO:0004930 IBA
    G protein-coupled receptor activity GO:0004930 ISS
    G protein-coupled receptor activity GO:0004930 NAS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
    adenylate cyclase inhibitor activity GO:0010855 IBA
    adenylate cyclase inhibitor activity GO:0010855 ISS
    hydrolase activity GO:0016787 IEA
Biological Process
    cell surface receptor signaling pathway GO:0007166 IEA
    G protein-coupled receptor signaling pathway GO:0007186 ISS
    negative regulation of adenylate cyclase activity GO:0007194 ISS
    nervous system development GO:0007399 NAS
    visual perception GO:0007601 IBA
    visual perception GO:0007601 ISS
    sensory perception of sound GO:0007605 IBA
    sensory perception of sound GO:0007605 IMP
    positive regulation of protein kinase A signaling GO:0010739 ISS
    positive regulation of bone mineralization GO:0030501 ISS
    regulation of protein stability GO:0031647 ISS
    establishment of protein localization GO:0045184 ISS
    photoreceptor cell maintenance GO:0045494 IMP
    maintenance of animal organ identity GO:0048496 IMP
    inner ear development GO:0048839 ISS
    nervous system process GO:0050877 IMP
    detection of mechanical stimulus involved in sensory perception of sound GO:0050910 ISS
    sensory perception of light stimulus GO:0050953 IMP
    inner ear receptor cell differentiation GO:0060113 NAS
    inner ear receptor cell stereocilium organization GO:0060122 ISS
    cellular response to calcium ion GO:0071277 IBA
    cellular response to calcium ion GO:0071277 ISS
    self proteolysis GO:0097264 ISS
    cell-cell adhesion GO:0098609 NAS
Subcellular Localization
    photoreceptor inner segment GO:0001917 IEA
    stereocilia ankle link GO:0002141 ISS
    stereocilia ankle link complex GO:0002142 ISS
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 ISS
    cell surface GO:0009986 IDA
    membrane GO:0016020 NAS
    stereocilium GO:0032420 IBA
    receptor complex GO:0043235 IDA
    stereocilium membrane GO:0060171 IEA
    extracellular exosome GO:0070062 HDA
    periciliary membrane compartment GO:1990075 ISS
    USH2 complex GO:1990696 ISS
 Experiment description of studies that identified ADGRV1 in exosomes
1
Experiment ID 274
MISEV standards
EM
Biophysical techniques
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
AIF
Negative markers
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ADGRV1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HPSE2  
Affinity Capture-MS Homo sapiens
2 FAM169B  
Affinity Capture-MS Homo sapiens
3 CSTL1  
Affinity Capture-MS Homo sapiens
4 GPIHBP1  
Affinity Capture-MS Homo sapiens
5 CD96  
Affinity Capture-MS Homo sapiens
6 INSL4  
Affinity Capture-MS Homo sapiens
7 CEACAM8 1088
Affinity Capture-MS Homo sapiens
8 SERPINA12  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 SIAE 54414
Affinity Capture-MS Homo sapiens
10 DVL2 1856
Affinity Capture-MS Homo sapiens
11 SCGB1D1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 C2CD4B  
Affinity Capture-MS Homo sapiens
13 CALR3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 TAZ  
Affinity Capture-MS Homo sapiens
15 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 FAM19A5 25817
Affinity Capture-MS Homo sapiens
17 GGH 8836
Affinity Capture-MS Homo sapiens
18 EDDM3A  
Affinity Capture-MS Homo sapiens
19 PNLIPRP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 IFNE  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 LOC254896  
Affinity Capture-MS Homo sapiens
22 UCN3  
Affinity Capture-MS Homo sapiens
23 CMA1  
Affinity Capture-MS Homo sapiens
24 SLAMF1 6504
Affinity Capture-MS Homo sapiens
25 NMS  
Affinity Capture-MS Homo sapiens
26 AURKB 9212
Affinity Capture-MS Homo sapiens
27 SCGB1D4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 LAG3  
Affinity Capture-MS Homo sapiens
29 FAM150B  
Affinity Capture-MS Homo sapiens
30 NTN5  
Affinity Capture-MS Homo sapiens
31 FBXO2 26232
Affinity Capture-MS Homo sapiens
32 PRSS37  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
33 XCL1  
Affinity Capture-MS Homo sapiens
34 CCL19  
Affinity Capture-MS Homo sapiens
35 NXPH2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 PROK2  
Affinity Capture-MS Homo sapiens
37 XAGE1B  
Affinity Capture-MS Homo sapiens
38 RNASE4 6038
Affinity Capture-MS Homo sapiens
39 RPL28 6158
Affinity Capture-MS Homo sapiens
40 PRSS1 5644
Affinity Capture-MS Homo sapiens
41 CD160  
Affinity Capture-MS Homo sapiens
42 HYOU1 10525
Affinity Capture-MS Homo sapiens
43 DHFRL1  
Affinity Capture-MS Homo sapiens
44 DNAJC3 5611
Affinity Capture-MS Homo sapiens
45 GPHA2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 DDX58 23586
Affinity Capture-RNA Homo sapiens
47 PDGFB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 ADAMTS17  
Affinity Capture-MS Homo sapiens
50 PSG8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 DEFB135  
Affinity Capture-MS Homo sapiens
52 DKKL1  
Affinity Capture-MS Homo sapiens
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