Gene description for ADGRV1
Gene name adhesion G protein-coupled receptor V1
Gene symbol ADGRV1
Other names/aliases FEB4
GPR98
MASS1
USH2B
USH2C
VLGR1
VLGR1b
Species Homo sapiens
 Database cross references - ADGRV1
ExoCarta ExoCarta_84059
Entrez Gene 84059
HGNC 17416
MIM 602851
UniProt Q8WXG9  
 ADGRV1 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
Urine 19056867    
 Gene ontology annotations for ADGRV1
Molecular Function
    myosin binding GO:0017022 IEA
    G-protein coupled receptor activity GO:0004930 NAS
    calcium ion binding GO:0005509 IDA
    protein binding GO:0005515 IPI
Biological Process
    G-protein coupled receptor signaling pathway GO:0007186 IEA
    maintenance of organ identity GO:0048496 IMP
    nervous system development GO:0007399 NAS
    sensory perception of sound GO:0007605 IMP
    inner ear receptor stereocilium organization GO:0060122 IEA
    neurological system process GO:0050877 IMP
    single organismal cell-cell adhesion GO:0016337 NAS
    photoreceptor cell maintenance GO:0045494 IMP
    detection of mechanical stimulus involved in sensory perception of sound GO:0050910 IEA
    visual perception GO:0007601 IEA
    sensory perception of light stimulus GO:0050953 IMP
Subcellular Localization
    periciliary membrane compartment GO:1990075 IEA
    cytoplasm GO:0005737 IDA
    membrane GO:0016020 NAS
    extracellular exosome GO:0070062 IDA
    stereocilia ankle link complex GO:0002142 IEA
    receptor complex GO:0043235 IDA
    cell surface GO:0009986 IDA
    integral component of membrane GO:0016021 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
 Experiment description of studies that identified ADGRV1 in exosomes
1
Experiment ID 274
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|RAB5A
EV Cytosolic markers
CD9|CD82|CD63|CD81
EV Membrane markers
AIF
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for ADGRV1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADGRV1 is involved
No pathways found





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