Gene description for CREB5
Gene name cAMP responsive element binding protein 5
Gene symbol CREB5
Other names/aliases CRE-BPA
CREB-5
Species Homo sapiens
 Database cross references - CREB5
ExoCarta ExoCarta_9586
Entrez Gene 9586
HGNC 16844
UniProt Q02930  
 CREB5 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for CREB5
Molecular Function
    sequence-specific DNA binding GO:0043565 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription GO:0001077 IEA
    metal ion binding GO:0046872 IEA
Biological Process
    adipose tissue development GO:0060612 IEA
    positive regulation of transcription, DNA-templated GO:0045893 IDA
    transcription from RNA polymerase II promoter GO:0006366 TAS
    fat cell differentiation GO:0045444 IEA
    positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA
Subcellular Localization
    nucleus GO:0005634 IC
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified CREB5 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
AQP2
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CREB5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CREB5 9586
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
2 JUN 3725
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which CREB5 is involved
No pathways found





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