Gene description for CREB5
Gene name cAMP responsive element binding protein 5
Gene symbol CREB5
Other names/aliases CRE-BPA
CREB-5
Species Homo sapiens
 Database cross references - CREB5
ExoCarta ExoCarta_9586
Vesiclepedia VP_9586
Entrez Gene 9586
HGNC 16844
UniProt Q02930  
 CREB5 identified in sEVs derived from the following tissue/cell type
Neuroblastoma cells 25944692    
Urine 19056867    
 Gene ontology annotations for CREB5
Molecular Function
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 IBA
    DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 ISA
    DNA-binding transcription factor activity GO:0003700 IDA
    protein binding GO:0005515 IPI
    cAMP response element binding GO:0035497 IBA
    identical protein binding GO:0042802 IPI
    metal ion binding GO:0046872 IEA
    sequence-specific double-stranded DNA binding GO:1990837 IDA
Biological Process
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    positive regulation of DNA-templated transcription GO:0045893 IDA
Subcellular Localization
    chromatin GO:0000785 ISA
    nucleus GO:0005634 IC
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified CREB5 in sEVs
1
Experiment ID 224
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
2
Experiment ID 63
MISEV standards
Biophysical techniques
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for CREB5
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 CIB4  
Two-hybrid Homo sapiens
2 KRTAP12-3  
Two-hybrid Homo sapiens
3 LCE2A  
Two-hybrid Homo sapiens
4 LGR4 55366
Affinity Capture-MS Homo sapiens
5 KRTAP10-11  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
6 FRS3 10817
Two-hybrid Homo sapiens
7 LCE2C  
Two-hybrid Homo sapiens
8 KIFC3 3801
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 NOTCH2NL 388677
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
10 UFSP1  
Two-hybrid Homo sapiens
11 KRTAP5-4  
Two-hybrid Homo sapiens
12 MGAT5B  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
13 BRCA1 672
Affinity Capture-MS Homo sapiens
14 JUND 3727
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 LMX1B  
Two-hybrid Homo sapiens
16 SPOPL  
Two-hybrid Homo sapiens
17 KRTAP5-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
18 KRTAP7-1  
Two-hybrid Homo sapiens
19 RNF208  
Two-hybrid Homo sapiens
20 KRTAP4-12  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
21 PRR22  
Two-hybrid Homo sapiens
22 KRTAP19-2  
Two-hybrid Homo sapiens
23 SSC4D  
Two-hybrid Homo sapiens
24 KRTAP2-4  
Two-hybrid Homo sapiens
25 KRTAP10-10  
Two-hybrid Homo sapiens
26 KRT40  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
27 COL8A1 1295
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 ZMYND11 10771
Affinity Capture-MS Homo sapiens
29 KRTAP4-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
30 MTUS2 23281
Two-hybrid Homo sapiens
31 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 ANAPC11  
Two-hybrid Homo sapiens
33 RGS20 8601
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
34 CENPQ  
Affinity Capture-MS Homo sapiens
35 MMADHC  
Two-hybrid Homo sapiens
36 KRTAP10-1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
37 KRT83  
Two-hybrid Homo sapiens
38 KRTAP19-5  
Two-hybrid Homo sapiens
39 KPRP 448834
Two-hybrid Homo sapiens
40 KRTAP5-2  
Two-hybrid Homo sapiens
41 KRTAP4-4  
Two-hybrid Homo sapiens
42 KRTAP4-1  
Two-hybrid Homo sapiens
43 KRTAP5-6  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
44 C15orf59  
Affinity Capture-MS Homo sapiens
45 ADAMTSL4  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
46 KRTAP8-1  
Two-hybrid Homo sapiens
47 KRTAP22-1  
Two-hybrid Homo sapiens
48 ATF7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 FHL3 2275
Two-hybrid Homo sapiens
50 ZNF330  
Two-hybrid Homo sapiens
51 TSPAN4 7106
Two-hybrid Homo sapiens
52 CTBP1 1487
Affinity Capture-MS Homo sapiens
53 JDP2  
Two-hybrid Homo sapiens
54 TRIM42  
Two-hybrid Homo sapiens
55 BACH1 571
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 ATF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 LGALS13  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
58 KRTAP6-2  
Two-hybrid Homo sapiens
59 SPRY4 81848
Two-hybrid Homo sapiens
60 CYSRT1 375791
Two-hybrid Homo sapiens
61 SLX4  
Affinity Capture-MS Homo sapiens
62 RBP3  
Two-hybrid Homo sapiens
63 CNFN  
Two-hybrid Homo sapiens
64 FOSB  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
65 MLLT6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
66 FBLN5 10516
Affinity Capture-MS Homo sapiens
67 ID3  
Two-hybrid Homo sapiens
68 SIVA1  
Two-hybrid Homo sapiens
69 CERCAM 51148
Two-hybrid Homo sapiens
70 TSR2  
Two-hybrid Homo sapiens
71 KRTAP10-7  
Two-hybrid Homo sapiens
72 KRT85  
Two-hybrid Homo sapiens
73 LCE5A  
Two-hybrid Homo sapiens
74 RNF144B  
Two-hybrid Homo sapiens
75 SNAPC5  
Two-hybrid Homo sapiens
76 KRTAP1-3  
Two-hybrid Homo sapiens
77 MDFI  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
78 AHCYL1 10768
Affinity Capture-MS Homo sapiens
79 KRT86  
Two-hybrid Homo sapiens
80 CDPF1  
Two-hybrid Homo sapiens
81 KRTAP10-8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
82 KRTAP1-5  
Two-hybrid Homo sapiens
83 KRTAP9-3  
Two-hybrid Homo sapiens
84 CEBPG  
Affinity Capture-MS Homo sapiens
85 KRTAP10-3  
Two-hybrid Homo sapiens
86 HOXA1 3198
Two-hybrid Homo sapiens
87 BATF3  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
88 JUN 3725
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 KRT15 3866
Two-hybrid Homo sapiens
90 KRTAP5-11  
Two-hybrid Homo sapiens
91 NADSYN1 55191
Two-hybrid Homo sapiens
92 FOS 2353
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
93 KRTAP2-3  
Two-hybrid Homo sapiens
94 SPRY1 10252
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
95 TRIM27  
Two-hybrid Homo sapiens
96 JUNB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 KRTAP9-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
98 LCE4A  
Two-hybrid Homo sapiens
99 KRTAP6-1  
Two-hybrid Homo sapiens
100 KRTAP3-2  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
101 CPSF3L 54973
Two-hybrid Homo sapiens
102 TSGA10  
Two-hybrid Homo sapiens
103 KRTAP6-3  
Two-hybrid Homo sapiens
104 KRTAP10-5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
105 FOSL2  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 LCE1C  
Two-hybrid Homo sapiens
107 BACH2 60468
Affinity Capture-MS Homo sapiens
108 TRIP6 7205
Two-hybrid Homo sapiens
109 KRTAP3-1  
Two-hybrid Homo sapiens
110 ANKFY1 51479
Affinity Capture-MS Homo sapiens
111 TRAF2 7186
Two-hybrid Homo sapiens
112 SPRY2 10253
Two-hybrid Homo sapiens
113 PRDM14  
Two-hybrid Homo sapiens
114 KRTAP19-3  
Two-hybrid Homo sapiens
115 WWOX 51741
Two-hybrid Homo sapiens
116 FOSL1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
117 KRTAP19-6  
Two-hybrid Homo sapiens
118 KRTAP9-4  
Two-hybrid Homo sapiens
119 NBPF19  
Two-hybrid Homo sapiens
120 AJUBA  
Two-hybrid Homo sapiens
121 LITAF 9516
Two-hybrid Homo sapiens
122 RCHY1  
Two-hybrid Homo sapiens
123 PPP2R2D 55844
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 KRTAP5-7  
Two-hybrid Homo sapiens
125 CREB5 9586
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
126 KRTAP9-8  
Two-hybrid Homo sapiens
127 FST 10468
Two-hybrid Homo sapiens
128 SPRY3  
Two-hybrid Homo sapiens
129 KRTAP4-5  
Two-hybrid Homo sapiens
130 CYP21A2  
Two-hybrid Homo sapiens
131 TRIM23 373
Two-hybrid Homo sapiens
132 ALPP 250
Two-hybrid Homo sapiens
133 SPATA12  
Two-hybrid Homo sapiens
134 RIMBP3 85376
Two-hybrid Homo sapiens
135 IGFBP6 3489
Two-hybrid Homo sapiens
136 SPRED1 161742
Two-hybrid Homo sapiens
137 RBCK1  
Two-hybrid Homo sapiens
138 ARIH1 25820
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 EFEMP2 30008
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
140 KRTAP10-9  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CREB5 is involved
No pathways found





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