Gene description for CPSF3L
Gene name cleavage and polyadenylation specific factor 3-like
Gene symbol CPSF3L
Other names/aliases CPSF73L
INT11
INTS11
RC-68
RC68
Species Homo sapiens
 Database cross references - CPSF3L
ExoCarta ExoCarta_54973
Entrez Gene 54973
HGNC 26052
MIM 611354
UniProt Q5TA45  
 CPSF3L identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
Thymus 23844026    
 Gene ontology annotations for CPSF3L
Molecular Function
    protein binding GO:0005515 IPI
    hydrolase activity GO:0016787 IEA
Biological Process
    snRNA processing GO:0016180 IDA
Subcellular Localization
    cytoplasm GO:0005737 IEA
    integrator complex GO:0032039 IDA
    blood microparticle GO:0072562 IDA
 Experiment description of studies that identified CPSF3L in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
2
Experiment ID 217
ISEV standards
EM
EV Biophysical techniques
TSG101
EV Cytosolic markers
CD81|CD9|CD63
EV Membrane markers
EV Negative markers
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for CPSF3L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PLSCR1 5359
Two-hybrid Homo sapiens
2 TRIP13 9319
Two-hybrid Homo sapiens
3 MDFI  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CPSF3L is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here