Gene description for INTS3
Gene name integrator complex subunit 3
Gene symbol INTS3
Other names/aliases C1orf193
C1orf60
INT3
SOSS-A
SOSSA
Species Homo sapiens
 Database cross references - INTS3
ExoCarta ExoCarta_65123
Entrez Gene 65123
HGNC 26153
MIM 611347
UniProt Q68E01  
 INTS3 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for INTS3
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    snRNA processing GO:0016180 IDA
    DNA repair GO:0006281 IMP
    response to ionizing radiation GO:0010212 IMP
    mitotic cell cycle checkpoint GO:0007093 IMP
    cellular response to DNA damage stimulus GO:0006974 IMP
Subcellular Localization
    SOSS complex GO:0070876 IDA
    integrator complex GO:0032039 IDA
    nucleus GO:0005634 IDA
 Experiment description of studies that identified INTS3 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for INTS3
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which INTS3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here