Gene description for ENY2
Gene name enhancer of yellow 2 homolog (Drosophila)
Gene symbol ENY2
Other names/aliases DC6
e(y)2
Species Homo sapiens
 Database cross references - ENY2
ExoCarta ExoCarta_56943
Vesiclepedia VP_56943
Entrez Gene 56943
HGNC 24449
UniProt Q9NPA8  
 ENY2 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for ENY2
Molecular Function
    chromatin binding GO:0003682 IBA
    transcription coactivator activity GO:0003713 IBA
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    nuclear receptor coactivator activity GO:0030374 IDA
Biological Process
    regulation of DNA repair GO:0006282 NAS
    chromatin organization GO:0006325 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IBA
    regulation of transcription by RNA polymerase II GO:0006357 IDA
    transcription elongation by RNA polymerase II GO:0006368 IEA
    protein transport GO:0015031 IEA
    poly(A)+ mRNA export from nucleus GO:0016973 IBA
    poly(A)+ mRNA export from nucleus GO:0016973 IMP
    regulation of RNA splicing GO:0043484 NAS
    positive regulation of DNA-templated transcription GO:0045893 IDA
    positive regulation of DNA-templated transcription GO:0045893 NAS
    negative regulation of insulin secretion involved in cellular response to glucose stimulus GO:0061179 IEA
Subcellular Localization
    SAGA complex GO:0000124 IBA
    SAGA complex GO:0000124 IDA
    SAGA complex GO:0000124 NAS
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 IDA
    transcription factor TFTC complex GO:0033276 NAS
    nuclear pore nuclear basket GO:0044615 IDA
    transcription export complex 2 GO:0070390 IDA
    DUBm complex GO:0071819 IBA
    DUBm complex GO:0071819 IDA
 Experiment description of studies that identified ENY2 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for ENY2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 EIF3A 8661
Affinity Capture-MS Homo sapiens
3 HIST1H2BC 8347
Cross-Linking-MS (XL-MS) Homo sapiens
4 TADA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 RPSA 3921
Affinity Capture-MS Homo sapiens
6 HNRNPC 3183
Affinity Capture-MS Homo sapiens
7 RPS28 6234
Affinity Capture-MS Homo sapiens
8 RPS3A 6189
Affinity Capture-MS Homo sapiens
9 TRRAP 8295
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 RPS4X 6191
Affinity Capture-MS Homo sapiens
11 ATXN7L2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 TADA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 YWHAE 7531
Cross-Linking-MS (XL-MS) Homo sapiens
14 RPL13A 23521
Affinity Capture-MS Homo sapiens
15 RPL37A 6168
Affinity Capture-MS Homo sapiens
16 ACTC1 70
Proximity Label-MS Homo sapiens
17 HIST1H2BH 8345
Cross-Linking-MS (XL-MS) Homo sapiens
18 RPS19 6223
Affinity Capture-MS Homo sapiens
19 RPL10 6134
Affinity Capture-MS Homo sapiens
20 RPL15 6138
Affinity Capture-MS Homo sapiens
21 PRPS1L1 221823
Affinity Capture-MS Homo sapiens
22 C7orf76  
Affinity Capture-MS Homo sapiens
23 EIF4A1 1973
Affinity Capture-MS Homo sapiens
24 RPL18A 6142
Affinity Capture-MS Homo sapiens
25 HIST1H2BL 8340
Cross-Linking-MS (XL-MS) Homo sapiens
26 APP 351
Reconstituted Complex Homo sapiens
27 RPS3 6188
Affinity Capture-MS Homo sapiens
28 APEX1 328
Affinity Capture-RNA Homo sapiens
29 RPS18 6222
Affinity Capture-MS Homo sapiens
30 ATXN7L3B 552889
Affinity Capture-MS Homo sapiens
31 ATXN7L1 222255
Affinity Capture-MS Homo sapiens
32 RPS20 6224
Affinity Capture-MS Homo sapiens
33 TAF9 6880
Affinity Capture-MS Homo sapiens
34 RPL39 6170
Affinity Capture-MS Homo sapiens
35 CIAPIN1 57019
Co-fractionation Homo sapiens
36 H1FX 8971
Affinity Capture-MS Homo sapiens
37 EIF3B 8662
Affinity Capture-MS Homo sapiens
38 RPL24 6152
Affinity Capture-MS Homo sapiens
39 Naa10  
Affinity Capture-MS Mus musculus
40 NPM1 4869
Affinity Capture-MS Homo sapiens
41 RPS9 6203
Affinity Capture-MS Homo sapiens
42 KTN1 3895
Affinity Capture-MS Homo sapiens
43 USP27X  
Affinity Capture-MS Homo sapiens
44 RPS6 6194
Affinity Capture-MS Homo sapiens
45 MECP2 4204
Affinity Capture-MS Homo sapiens
46 MYCN  
Affinity Capture-MS Homo sapiens
47 RPS11 6205
Affinity Capture-MS Homo sapiens
48 GNB2L1 10399
Affinity Capture-MS Homo sapiens
49 PABPC4 8761
Affinity Capture-MS Homo sapiens
50 RPL19 6143
Affinity Capture-MS Homo sapiens
51 NEIL3  
Affinity Capture-MS Homo sapiens
52 TAF5L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 EIF2S3 1968
Affinity Capture-MS Homo sapiens
54 USP22 23326
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
55 RBMX 27316
Affinity Capture-MS Homo sapiens
56 EPB41L3 23136
Affinity Capture-MS Homo sapiens
57 AURKA 6790
Affinity Capture-MS Homo sapiens
58 RPL27 6155
Affinity Capture-MS Homo sapiens
59 EIF3K 27335
Affinity Capture-MS Homo sapiens
60 CPSF3L 54973
Affinity Capture-MS Homo sapiens
61 YTHDF2 51441
Affinity Capture-MS Homo sapiens
62 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
63 NEB 4703
Cross-Linking-MS (XL-MS) Homo sapiens
64 RPL9 6133
Affinity Capture-MS Homo sapiens
65 TOP2B 7155
Cross-Linking-MS (XL-MS) Homo sapiens
66 TAF10 6881
Affinity Capture-Western Homo sapiens
67 RPL4 6124
Affinity Capture-MS Homo sapiens
68 Rock1  
Affinity Capture-MS Mus musculus
69 SUPT7L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 TAF9B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 RPL5 6125
Affinity Capture-MS Homo sapiens
72 Kifc1  
Affinity Capture-MS Mus musculus
73 PABPC1 26986
Affinity Capture-MS Homo sapiens
74 TAF12  
Affinity Capture-MS Homo sapiens
75 RPL31 6160
Affinity Capture-MS Homo sapiens
76 NACA 4666
Affinity Capture-MS Homo sapiens
77 PEX14 5195
Affinity Capture-MS Homo sapiens
78 SUPT3H  
Affinity Capture-MS Homo sapiens
79 RPL27A 6157
Affinity Capture-MS Homo sapiens
80 RPLP1 6176
Affinity Capture-MS Homo sapiens
81 PABPN1 8106
Affinity Capture-MS Homo sapiens
82 DHX9 1660
Affinity Capture-MS Homo sapiens
83 RPLP0 6175
Affinity Capture-MS Homo sapiens
84 RPS16 6217
Affinity Capture-MS Homo sapiens
85 GOLGB1 2804
Cross-Linking-MS (XL-MS) Homo sapiens
86 CEBPA  
Protein-peptide Homo sapiens
87 TAF6L 10629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
88 CCDC18  
Cross-Linking-MS (XL-MS) Homo sapiens
89 RPL30 6156
Affinity Capture-MS Homo sapiens
90 RPL11 6135
Affinity Capture-MS Homo sapiens
91 CETN1  
Affinity Capture-MS Homo sapiens
92 DST 667
Cross-Linking-MS (XL-MS) Homo sapiens
93 EIF3G 8666
Affinity Capture-MS Homo sapiens
94 TMPO 7112
Affinity Capture-MS Homo sapiens
95 RPL32 6161
Affinity Capture-MS Homo sapiens
96 RPLP2 6181
Affinity Capture-MS Homo sapiens
97 RPL23 9349
Affinity Capture-MS Homo sapiens
98 RPS2 6187
Affinity Capture-MS Homo sapiens
99 RPL35 11224
Affinity Capture-MS Homo sapiens
100 PCDHB15  
Affinity Capture-MS Homo sapiens
101 C11orf49  
Two-hybrid Homo sapiens
102 RPL14 9045
Affinity Capture-MS Homo sapiens
103 RPS7 6201
Affinity Capture-MS Homo sapiens
104 RPL21 6144
Affinity Capture-MS Homo sapiens
105 RPL3 6122
Affinity Capture-MS Homo sapiens
106 PPIA 5478
Cross-Linking-MS (XL-MS) Homo sapiens
107 EPRS 2058
Affinity Capture-MS Homo sapiens
108 RPL7 6129
Affinity Capture-MS Homo sapiens
109 RPL29 6159
Affinity Capture-MS Homo sapiens
110 RPL36 25873
Affinity Capture-MS Homo sapiens
111 MYC  
Affinity Capture-MS Homo sapiens
112 RPS13 6207
Affinity Capture-MS Homo sapiens
113 RPL35A 6165
Affinity Capture-MS Homo sapiens
114 RPL22 6146
Affinity Capture-MS Homo sapiens
115 EIF3CL 728689
Affinity Capture-MS Homo sapiens
116 CCDC101  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 RPL18 6141
Affinity Capture-MS Homo sapiens
118 SF3B3 23450
Affinity Capture-MS Homo sapiens
119 MCM3AP  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
120 ATXN7L3  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 ILF3 3609
Affinity Capture-MS Homo sapiens
122 HUWE1 10075
Affinity Capture-MS Homo sapiens
123 EIF3D 8664
Affinity Capture-MS Homo sapiens
124 EIF3H 8667
Affinity Capture-MS Homo sapiens
125 H2AFX 3014
Co-fractionation Homo sapiens
126 RPL13 6137
Affinity Capture-MS Homo sapiens
127 GLUD1 2746
Affinity Capture-MS Homo sapiens
128 RPS25 6230
Affinity Capture-MS Homo sapiens
129 EIF3C 8663
Affinity Capture-MS Homo sapiens
130 KAT2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
131 SUPT20H 55578
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
132 HIST1H2BK 85236
Cross-Linking-MS (XL-MS) Homo sapiens
133 RPL6 6128
Affinity Capture-MS Homo sapiens
134 RPS21 6227
Affinity Capture-MS Homo sapiens
135 KAT2B  
Affinity Capture-Western Homo sapiens
Co-localization Homo sapiens
Affinity Capture-MS Homo sapiens
136 ATXN7  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 HNRNPA2B1 3181
Two-hybrid Homo sapiens
138 RPS12 6206
Affinity Capture-MS Homo sapiens
139 CETN3  
Affinity Capture-MS Homo sapiens
140 Smo  
Affinity Capture-MS Mus musculus
141 SRP72 6731
Affinity Capture-MS Homo sapiens
142 CAPRIN1 4076
Affinity Capture-MS Homo sapiens
143 HIST1H2BD 3017
Cross-Linking-MS (XL-MS) Homo sapiens
144 HSP90AA1 3320
Cross-Linking-MS (XL-MS) Homo sapiens
145 RPS5 6193
Affinity Capture-MS Homo sapiens
146 RPS15A 6210
Affinity Capture-MS Homo sapiens
147 RPL34 6164
Affinity Capture-MS Homo sapiens
148 UFL1 23376
Two-hybrid Homo sapiens
149 RPL10A 4736
Affinity Capture-MS Homo sapiens
150 RPL38 6169
Affinity Capture-MS Homo sapiens
151 RPS24 6229
Affinity Capture-MS Homo sapiens
152 RPS23 6228
Affinity Capture-MS Homo sapiens
153 RPL7A 6130
Affinity Capture-MS Homo sapiens
154 RPS8 6202
Affinity Capture-MS Homo sapiens
155 RPL8 6132
Affinity Capture-MS Homo sapiens
156 RPL28 6158
Affinity Capture-MS Homo sapiens
157 SERBP1 26135
Affinity Capture-MS Homo sapiens
158 PRRC2C 23215
Affinity Capture-MS Homo sapiens
159 RPL23A 6147
Affinity Capture-MS Homo sapiens
160 KRAS 3845
Synthetic Lethality Homo sapiens
161 C9orf72  
Affinity Capture-MS Homo sapiens
162 USP51  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 PRMT1 3276
Affinity Capture-MS Homo sapiens
164 RPL17 6139
Affinity Capture-MS Homo sapiens
165 TADA2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
166 EIF3L 51386
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which ENY2 is involved
PathwayEvidenceSource
Chromatin modifying enzymes IEA Reactome
Chromatin organization IEA Reactome
HATs acetylate histones IEA Reactome





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