Gene description for PRPS1L1
Gene name phosphoribosyl pyrophosphate synthetase 1-like 1
Gene symbol PRPS1L1
Other names/aliases PRPS1
PRPS3
PRPSL
PRS-III
Species Homo sapiens
 Database cross references - PRPS1L1
ExoCarta ExoCarta_221823
Entrez Gene 221823
HGNC 9463
MIM 611566
UniProt P21108  
 PRPS1L1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PRPS1L1
Molecular Function
    protein homodimerization activity GO:0042803 ISS
    ATP binding GO:0005524 ISS
    kinase activity GO:0016301 IEA
    ribose phosphate diphosphokinase activity GO:0004749 NAS
    magnesium ion binding GO:0000287 IEA
Biological Process
    nucleotide biosynthetic process GO:0009165 IEA
    phosphorylation GO:0016310 IEA
    ribonucleoside monophosphate biosynthetic process GO:0009156 IEA
    5-phosphoribose 1-diphosphate biosynthetic process GO:0006015 IEA
Subcellular Localization
    cellular_component GO:0005575 ND
 Experiment description of studies that identified PRPS1L1 in exosomes
1
Experiment ID 224
ISEV standards
✔
EM|AFM
EV Biophysical techniques
✔
Alix|TSG101
EV Cytosolic markers
✔
CD63|CD81
EV Membrane markers
✔
GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PRPS1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which PRPS1L1 is involved
PathwayEvidenceSource
5-Phosphoribose 1-diphosphate biosynthesis TAS Reactome





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