Gene description for PRPS1L1
Gene name phosphoribosyl pyrophosphate synthetase 1-like 1
Gene symbol PRPS1L1
Other names/aliases PRPS1
PRPS3
PRPSL
PRS-III
Species Homo sapiens
 Database cross references - PRPS1L1
ExoCarta ExoCarta_221823
Vesiclepedia VP_221823
Entrez Gene 221823
HGNC 9463
MIM 611566
UniProt P21108  
 PRPS1L1 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for PRPS1L1
Molecular Function
    magnesium ion binding GO:0000287 IEA
    ribose phosphate diphosphokinase activity GO:0004749 IBA
    ribose phosphate diphosphokinase activity GO:0004749 ISS
    ribose phosphate diphosphokinase activity GO:0004749 NAS
    ATP binding GO:0005524 ISS
    kinase activity GO:0016301 IEA
    protein homodimerization activity GO:0042803 ISS
Biological Process
    5-phosphoribose 1-diphosphate biosynthetic process GO:0006015 IBA
    5-phosphoribose 1-diphosphate biosynthetic process GO:0006015 IEA
    purine nucleotide biosynthetic process GO:0006164 IBA
    male gonad development GO:0008584 IEA
    ribonucleoside monophosphate biosynthetic process GO:0009156 IEA
Subcellular Localization
    ribose phosphate diphosphokinase complex GO:0002189 IBA
    cytoplasm GO:0005737 IBA
 Experiment description of studies that identified PRPS1L1 in exosomes
1
Experiment ID 224
MISEV standards
EM|AFM
Biophysical techniques
Alix|TSG101|CD63|CD81
Enriched markers
GOLGA2
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors "Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S"
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for PRPS1L1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 INSIG1  
Affinity Capture-MS Homo sapiens
2 FOXF2  
Affinity Capture-MS Homo sapiens
3 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
4 TERF2  
Affinity Capture-MS Homo sapiens
5 PPIAL4G  
Affinity Capture-MS Homo sapiens
6 KLK5 25818
Affinity Capture-MS Homo sapiens
7 EMC9  
Affinity Capture-MS Homo sapiens
8 CHMP4C 92421
Affinity Capture-MS Homo sapiens
9 BRD2  
Affinity Capture-MS Homo sapiens
10 B3GNT3 10331
Affinity Capture-MS Homo sapiens
11 PRPSAP2 5636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 CAND1 55832
Affinity Capture-MS Homo sapiens
13 IL22RA2  
Affinity Capture-MS Homo sapiens
14 FTH1 2495
Affinity Capture-MS Homo sapiens
15 GHITM 27069
Affinity Capture-MS Homo sapiens
16 NIPSNAP3B 55335
Affinity Capture-MS Homo sapiens
17 PRPS2 5634
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
18 PDZD8 118987
Affinity Capture-MS Homo sapiens
19 ATG13 9776
Affinity Capture-MS Homo sapiens
20 NCAPH 23397
Affinity Capture-MS Homo sapiens
21 TERF1 7013
Affinity Capture-MS Homo sapiens
22 RASL11A  
Affinity Capture-MS Homo sapiens
23 SPRTN  
Affinity Capture-MS Homo sapiens
24 PTPDC1  
Affinity Capture-MS Homo sapiens
25 COPS5 10987
Affinity Capture-MS Homo sapiens
26 DHFRL1  
Affinity Capture-MS Homo sapiens
27 ENY2 56943
Affinity Capture-MS Homo sapiens
28 PODXL 5420
Affinity Capture-MS Homo sapiens
29 PRPS1 5631
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
30 NXPH1  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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