Gene description for FASLG
Gene name
Fas ligand (TNF superfamily, member 6)
Gene symbol
FASLG
Other names/aliases
ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6
Species
Homo sapiens
Database cross references - FASLG
ExoCarta
ExoCarta_356
Vesiclepedia
VP_356
Entrez Gene
356
HGNC
11936
MIM
134638
UniProt
P48023
FASLG identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells
15940614
Plasma
17076679
T cells
21252909
Gene ontology annotations for FASLG
Experiment description of studies that identified FASLG in exosomes
1
Experiment ID
22
MISEV standards
✘
EV Biophysical techniques
✔
CD63
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Western blotting Immunoelectron Microscopy
PubMed ID
15940614
Organism
Homo sapiens
Experiment description
Human colorectal cancer cells induce T-cell death through release of proapoptotic microvesicles: role in immune escape.
Authors
Huber V, Fais S, Iero M, Lugini L, Canese P, Squarcina P, Zaccheddu A, Colone M, Arancia G, Gentile M, Seregni E, Valenti R, Ballabio G, Belli F, Leo E, Parmiani G, Rivoltini L.
Journal name
GASTRO
Publication year
2005
Sample
Colorectal cancer cells
Sample name
SW403 1869col CRC28462
Isolation/purification methods
Differential centrifugation
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting Immunoelectron Microscopy FACS
2
Experiment ID
43
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD83
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Western blotting
PubMed ID
17076679
Organism
Homo sapiens
Experiment description
Specific isolation of placenta-derived exosomes from the circulation of pregnant women and their immunoregulatory consequences.
Authors
Sabapatha A, Gercel-Taylor C, Taylor DD
Journal name
AJRI
Publication year
2006
Sample
Plasma
Sample name
Plasma - Pregnant and not-pregnant women
Isolation/purification methods
Size exclusion Ultracentrifugation Immunobeads (CD3, CD19, CD56, CD83, PLAP)
Flotation density
-
Molecules identified in the study
Protein
Methods used in the study
Western blotting
3
Experiment ID
91
MISEV standards
✔
EM
EV Biophysical techniques
✔
LAMP1|CD63
EV Enriched markers
✘
EV Negative markers
✘
EV Particle analysis
Identified molecule
protein
Identification method
Western blotting
PubMed ID
21252909
Organism
Homo sapiens
Experiment description
Diacylglycerol kinase a regulates the formation and polarisation of mature multivesicular bodies involved in the secretion of Fas ligand-containing exosomes in T lymphocytes
Authors
Alonso R, Mazzeo C, Rodriguez MC, Marsh M, Fraile-Ramos A, Calvo V, Avila-Flores A, Merida I, Izquierdo M.
Journal name
CDD
Publication year
2011
Sample
T cells
Sample name
J-HM1-2.2
Isolation/purification methods
Differential centrifugation Ultracentrifugation
Flotation density
-
Molecules identified in the study
Protein Lipids
Methods used in the study
Western blotting FACS Immunofluorescence
Protein-protein interactions for FASLG
Protein Interactor
ExoCarta ID
Identification method
PubMed
Species
1
GRAP2
9402
Invivo
Homo sapiens
Invitro
Homo sapiens
2
CASP8
841
Co-purification
Homo sapiens
Affinity Capture-Western
Homo sapiens
3
FADD
8772
Co-purification
Homo sapiens
Affinity Capture-Western
Homo sapiens
4
MMP7
4316
Biochemical Activity
Homo sapiens
5
NCK1
4690
Invivo
Homo sapiens
6
GRB2
2885
Invivo
Homo sapiens
Invitro
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
7
MSSE
Invivo
Homo sapiens
8
FAS
355
Invivo
Homo sapiens
Invitro
Homo sapiens
Co-purification
Homo sapiens
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
9
EZR
7430
Invitro
Homo sapiens
Invivo
Homo sapiens
Co-purification
Homo sapiens
10
PACSIN2
11252
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
11
LCK
3932
Invivo
Homo sapiens
12
GRAP
Invivo
Homo sapiens
13
BID
Co-purification
Homo sapiens
14
TNFRSF6B
Invivo
Homo sapiens
Invivo
Homo sapiens
Affinity Capture-Western
Homo sapiens
15
APBB1
Invivo
Homo sapiens
16
PRPF40A
55660
Invivo
Homo sapiens
17
NCF1
Invivo
Homo sapiens
18
FN1
2335
Reconstituted Complex
Homo sapiens
19
ARHGDIA
396
Co-purification
Homo sapiens
20
TNFRSF10B
8795
Co-purification
Homo sapiens
21
FYN
2534
Invitro
Homo sapiens
22
PTPN13
5783
Invitro
Homo sapiens
23
CASP10
Co-purification
Homo sapiens
24
SRC
6714
Invivo
Homo sapiens
25
FNBP1
23048
Reconstituted Complex
Homo sapiens
Affinity Capture-Western
Homo sapiens
Affinity Capture-MS
Homo sapiens
26
PIK3R1
5295
Invivo
Homo sapiens
27
MSN
4478
Co-purification
Homo sapiens
28
DMD
Invivo
Homo sapiens
29
RHOA
387
Co-purification
Homo sapiens
30
MAPK8
5599
Co-purification
Homo sapiens
31
TNFRSF1A
7132
Co-purification
Homo sapiens
32
SUMO1
7341
Two-hybrid
Homo sapiens
View the network
image/svg+xml
Pathways in which FASLG is involved