Gene description for MMP7
Gene name matrix metallopeptidase 7
Gene symbol MMP7
Other names/aliases MMP-7
MPSL1
PUMP-1
Species Homo sapiens
 Database cross references - MMP7
ExoCarta ExoCarta_4316
Vesiclepedia VP_4316
Entrez Gene 4316
HGNC 7174
MIM 178990
UniProt P09237  
 MMP7 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 17956143    
Pancreatic duct fluid 29339034    
 Gene ontology annotations for MMP7
Molecular Function
    metalloendopeptidase activity GO:0004222 IEA
    zinc ion binding GO:0008270 IEA
Biological Process
    collagen catabolic process GO:0030574 TAS
    response to drug GO:0042493 IEA
    proteolysis GO:0006508 IEA
    defense response to Gram-positive bacterium GO:0050830 IEA
    regulation of cell proliferation GO:0042127 IEA
    extracellular matrix disassembly GO:0022617 TAS
    antibacterial peptide biosynthetic process GO:0002780 IEA
    antibacterial peptide secretion GO:0002779 IEA
    extracellular matrix organization GO:0030198 TAS
    defense response to Gram-negative bacterium GO:0050829 IEA
Subcellular Localization
    extracellular region GO:0005576 TAS
    extracellular space GO:0005615 TAS
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified MMP7 in exosomes
1
Experiment ID 20
MISEV standards
✔
EM
EV Biophysical techniques
✔
HSP90|CD63|CD81|LAMP1
EV Enriched markers
✔
GOLGA2|cytochrome c
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17956143    
Organism Homo sapiens
Experiment description Proteomic analysis of microvesicles derived from human colorectal cancer cells.
Authors Choi DS, Lee JM, Park GW, Lim HW, Bang JY, Kim YK, Kwon KH, Kwon HJ, Kim KP, Gho YS
Journal name JPR
Publication year 2007
Sample Colorectal cancer cells
Sample name HT29
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Diafiltration
Flotation density 1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
2
Experiment ID 622
MISEV standards
✔
EM
EV Biophysical techniques
EV Enriched markers
✔
GOLGA2|CYC1
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 29339034    
Organism Homo sapiens
Experiment description Extracellular matrix proteins and carcinoembryonic antigen-related cell adhesion molecules characterize pancreatic duct fluid exosomes in patients with pancreatic cancer
Authors Zheng J, Hernandez JM, Doussot A, Bojmar L, Zambirinis CP, Costa-Silva B, van Beek EJAH, Mark MT, Molina H, Askan G, Basturk O, Gonen M, Kingham TP, Allen PJ, D'Angelica MI, DeMatteo RP, Lyden D, Jarnagin WR.
Journal name HPB
Publication year 2018
Sample Pancreatic duct fluid
Sample name From patients with Pancreatic ductal adenocarcinoma
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MMP7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 HBEGF 1839
Affinity Capture-Western Homo sapiens
2 CD44 960
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
3 FASLG 356
Biochemical Activity Homo sapiens
4 MMP1 4312
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
5 BCAN  
Affinity Capture-MS Homo sapiens
Biochemical Activity Homo sapiens
6 MMP9 4318
Invivo Homo sapiens
Affinity Capture-MS Homo sapiens
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